Consequences, 行动, and Intention as Factors - 麻省理工学院人工智能研究专业

Consequences, 行动, and Intention as Factors
in Moral Judgments: An fMRI Investigation

Jana Schaich Borg, Catherine Hynes, John Van Horn, Scott Grafton,
and Walter Sinnott-Armstrong

抽象的

& The traditional philosophical doctrines of Consequentialism,
Doing and Allowing, and Double Effect prescribe that moral
judgments and decisions should be based on consequences,
行动 (as opposed to inaction), and intention. This study uses
functional magnetic resonance imaging to investigate how these
three factors affect brain processes associated with moral
判断. We find the following: (1) Moral scenarios involving
only a choice between consequences with different amounts of
harm elicit activity in similar areas of the brain as analogous
nonmoral scenarios; (2) Compared to analogous nonmoral
scenarios, moral scenarios in which action and inaction result in
the same amount of harm elicit more activity in areas associated
with cognition (such as the dorsolateral prefrontal cortex) 和
less activity in areas associated with emotion (例如

orbitofrontal cortex and temporal pole); (3) Compared to
analogous nonmoral scenarios, conflicts between goals of
minimizing harm and of refraining from harmful action elicit
more activity in areas associated with emotion (眶额
cortex and temporal pole) and less activity in areas associated
with cognition (including the angular gyrus and superior frontal
gyrus); (4) Compared to moral scenarios involving only
unintentional harm, moral scenarios involving intentional harm
elicit more activity in areas associated with emotion (orbito-
frontal cortex and temporal pole) and less activity in areas
associated with cognition (including the angular gyrus and
superior frontal gyrus). These findings suggest that different
kinds of moral
judgment are preferentially supported by
distinguishable brain systems. &

介绍

judgments’’

Ever since Socrates debated sophists and stoics wran-
gled with skeptics, philosophers have argued about
whether moral judgments are based on reason or on
情感. Although definitions of morality may vary
across cultures and philosophies in other ways, 全部
definitions of ‘‘moral
include judgments
of the rightness or wrongness of acts that knowingly
cause harm to people other than the agent. 这些
central moral
judgments are distinct from economic
or prudential judgments based on the agent’s own in-
terest, both because the moral judgments depend on
interests of other people and because they focus on
harms as opposed to, 说, 乐趣. The present study
addresses core moral judgments of this kind (Nichols,
2004).

To investigate whether such core moral judgments are
based on emotion or on reason, these terms must first
be defined. 为了我们的目的, ‘‘emotions’’ are immedi-
ate valenced reactions that may or may not be con-
focus on emotions in the form of
scious. 我们将
negative affect. 相比之下, ‘‘reason’’ is neither valenced
nor immediate insofar as reasoning need not incline us

Dartmouth College

toward any specific feeling and combines prior informa-
tion with new beliefs or conclusions and usually comes
in the form of cognitive manipulations (such as evaluat-
ing alternatives) that require working memory. Emotion
might still affect, or even be necessary for, 推理
(Damasio, 1994), but emotion and reasoning remain
distinct components in an overall process of decision
制作.

In modern times, Hume (1888) and many utilitarian
philosophers based morality on emotion or sentiment
via what the former called ‘‘sympathy’’ and what con-
temporary psychologists call ‘‘empathy.’’ In their view,
core moral judgments arise from an immediate aversive
reaction to perceived or imagined harms to victims of
actions that are judged as immoral only after and
because of this emotional reaction. 相比之下, 康德
(1959) insisted that his basic nonutilitarian moral prin-
原则 (the categorical imperative) could be justified by
pure reason alone, and particular judgments could then
be reached by reasoning from his basic principle, 全部
without any help from emotion. Although somewhat
transformed, this fundamental debate still rages among
philosophers today.
Such traditional

issues are difficult to settle in an
armchair, yet some progress has been made with the
help of recent brain imaging techniques. Studies using

D 2006 麻省理工学院

认知神经科学杂志 18:5, PP. 803–817

D
哦
w
n
我
哦
A
d
e
d

F
r
哦
米

我

/
j

t
t

F
/

我
t
.

:
/
/

D
H
哦
t
w
t
p
n
:
哦
/
A
/
d
米
e
我
d
t
F
r
p
哦
r
米
C
.
H
s
我
p
我
v
d
e
我
r
r
e
C
C
H
t
.
米
A
我
r
e
.
d
C
你
哦
米
哦
/
C
j
n
哦
A
C
r
t
n
我
C
/
e
A
–
r
p
t
d
我
C
1
我
8
e
5
–
8
p
0
d
3
F
/
1
1
9
8
3
5
/
8
5
5
/
4
8
0
哦
3
C
/
n
1
2
7
0
5
0
6
6
1
1
8
8
8
/
5
j
8
哦
0
C
3
n
p
.
d
2
0
乙
0
y
6
G
.
你
1
e
8
s
.
t
5
哦
.
n
8
0
0
8
3
S
.
p
e
p
d
F
e
米
乙
乙
y
e
r
G
2
你
0
e
2
s
3
t

/
j

哦
n

1
8

中号
A
y

2
0
2
1

functional magnetic resonance imaging (功能磁共振成像) surpris-
ingly suggest that neither Kant nor Hume had the whole
truth, and that some moral
judgments involve more
emotion whereas others involve more reasoning. 为了
例子, neural systems associated with emotions are
activated more by personal moral dilemmas than by
impersonal moral dilemmas (Greene, Nystrom, Engell,
& Darley, 2004; Greene, Sommerville, Nystrom, Darley,
& 科恩, 2001). Personal moral dilemmas were labeled
‘‘personal’’ because the agent gets ‘‘up close and per-
sonal’’ with the victim in most such cases. Greene,
Nystrom, 等人. (2004) and Greene, Sommerville, 等人.
(2001) formally define personal moral dilemmas, 和-
out reference to physical proximity, as cases where an
otherwise desirable action is (1) likely to cause serious
bodily harm (2) to a particular person or group of
人 (3) not by deflecting an existing threat onto a
different party. A paradigm personal moral dilemma is
the footbridge case, where the only way to save five
people from a runaway trolley is to push a fat man off of
a footbridge in front of the trolley so as to stop the
trolley before it hits the five people. A paradigm imper-
sonal moral dilemma is the sidetrack case, 哪里的
only way to save five people is to redirect a runaway
trolley onto a sidetrack where it will kill one person.
Most people judge that it is morally wrong to push the
fat man off the footbridge; fewer people judge that it is
morally wrong to redirect the trolley onto the sidetrack.
The question is why and how people make these con-
trasting moral judgments.

These trolley cases differ as to whether a threat is
已创建 (as in pushing the fat man) or merely deflected
(as in redirecting the trolley onto the sidetrack), 但
there are other differences as well. 例如, 这
agent gets closer to the victim in the footbridge case
and that the agent in the footbridge case could jump
in front of the trolley instead of pushing the fat man,
whereas this option is not available in the sidetrack case.
Such complications presumably explain why Greene,
Sommerville, 等人. (2001) admit that their distinction
between personal and impersonal scenarios is only ‘‘a
有用
‘first cut,’ an important but preliminary step
toward identifying the psychologically essential features
of circumstances that engage (or fail to engage) 我们的
emotions and that ultimately shape our moral
判断-
评论 . . .’’ (p. 2107).

The exploratory fMRI study reported here makes a
‘‘second cut’’ by evaluating three factors picked out by
traditional moral principles that might underlie the
distinction between personal and impersonal moral
问题. One classic moral theory is Consequentialism,
which claims roughly that we morally ought to do
whatever has the best consequences overall (Sinnott-
Armstrong, 2003). Opposed to Consequentialism are
two deontological principles. The Doctrine of Doing
and Allowing (DDA) says that it takes more to justify
doing harm than to justify allowing harm; 因此, 为了

例子, it is sometimes morally wrong to commit an
act of killing in circumstances where it would not be
morally wrong to let someone die by refraining from an
act of saving (Howard-Snyder, 2002). Redirecting the
trolley onto the sidetrack violates the DDA insofar as it
involves positive action that causes death and, 因此,
counts as killing, but the DDA is not violated by merely
letting someone drown to be able to save five other
drowning people. The Doctrine of Double Effect (DDE),
相比之下, holds that it takes more to justify harms that
were intended either as ends or as means than to justify
harms that were known but unintended side effects;
因此, 例如,
it is sometimes morally wrong to
intend death as a means when it would not be morally
wrong to cause that death as an unintended side effect
(McIntyre, 2004). Pushing the fat man in front of the
trolley in the footbridge case violates the DDE because
the agent intends to use the fat man as a means to stop
the trolley and save the five people on the main track. 在
对比, deflecting the trolley in the sidetrack case does
not violate the DDE because the victim’s death in that
case is only an unintended side effect that is not nec-
essary for the agent’s plan to succeed in saving the five
people on the main track. Both the DDA and the DDE
conflict with Consequentialism because these deonto-
logical principles claim that factors other than conse-
quences matter, so it is sometimes morally wrong to do
what has the best consequences overall.

An empirical study cannot, 当然, determine
which moral theory is correct or which acts are morally
wrong. That is not the purpose of our study. Our goal
is only to use traditional theories, which pick out factors
that affect many people’s moral intuitions, as tools to
explore neural systems involved in moral judgment. 这
factors used in this study play a significant role not only
in moral philosophy but also in law (because people are
usually not guilty of first-degree murder when they
merely let people die and do not intend death) 和
religion (such as when the Catholic Church cites a
prohibition on intended harm to justify its official posi-
tions on abortion and euthanasia). Psychological studies
have documented omission bias (Kahneman & Tversky,
1982) and intention bias (Hauser, 2006) in moral judg-
蒙特, substantiating the impact of action and intention
on law and religion. Other factors, such as proximity to
the victim and creation vs. deflection of a threat, 可能
also affect moral judgments but were not investigated
explicitly in this study.

Based on previous studies of neural correlates of
moral judgments (surveyed in Moll, de Oliveira-Souza,
& Eslinger, 2003; Greene & Haidt, 2002), we hypothe-
sized that: (1) the medial frontal gyrus (布罗德曼区
[BA] 10), (2) the frontopolar gyrus (BA 10), 和 (3) 这
posterior superior temporal sulcus (超导系统)/inferior parie-
tal lobe (BA 39) would be more active when considering
moral scenarios than when considering nonmoral sce-
narios, irrespective of consequences, 行动, and inten-

804

认知神经科学杂志

体积 18, 数字 5

D
哦
w
n
我
哦
A
d
e
d

F
r
哦
米

我

/
j

F
/

t
t

我
t
.

:
/
/

/
j

哦
n

1
8

中号
A
y

2
0
2
1

的. Hypotheses regarding the differential effects of
结果, 行动, and intention were then framed
with respect to anatomic circuits linked to emotion and
认识. The paralimbic system, including the amyg-
dala, cingulate cortex, hippocampal formation, 颞
pole, and ventromedial prefrontal (including orbitofron-
的) cortex (Mesulam, 2000), has been credited as the
‘‘emotional’’ system of the brain, whereas the ‘‘central
executive’’ system (Baddeley, 1986), including regions of
the parietal lobe and lateral regions of the prefrontal
cortex, has been credited as the ‘‘cognitive’’ system of
大脑 (磨坊主 & 科恩, 2001). We hypothesized that
negative affect or emotion would be associated with
violations of established moral doctrines, 因此 (4)
the paralimbic system would be activated more in
thinking about actions that cause harm (and thus violate
the DDA) than in thinking about similarly harmful non-
actions or action omissions. We further hypothesized (5)
that the paralimbic system would be more activated
when thinking about intending harm as a means (哪个
violates the DDE) than in thinking about causing harm
as an unintended side effect. 反过来, cognitive
regions of the brain involved in reasoning would be
activated relatively more in considering moral scenarios
that did not include violations of either the DDA or the
DDE.

Another factor that is often said to affect emotion and
道德
judgment is the language used to describe a
scenario. Past studies of moral judgment seem to de-
scribe moral or personal moral scenarios with more
colorful language than their nonmoral or ‘‘impersonal’’
moral counterparts. (Greene Nystrom, 等人。, 2004;
Greene, Sommerville, 等人。, 2001) 如果是这样, this confound
might explain greater activations observed in emotional
系统. To test the effects of language, we presented
each moral scenario in both dramatic (colorful) 和
muted (noncolorful) 语言. We hypothesized (6)
that moral scenarios presented in a colorful language
would activate regions of the paralimbic system more
than otherwise similar moral scenarios presented in a
plain language.

The experimental design used to test these hypothe-
ses required some unique features. Previous studies on
moral judgment compared moral stimuli to non-moral
unpleasant stimuli (Moll, de Oliveira-Souza, Bramati,
& Grafman, 2002) or semantic improprieties (Heekeren,
Wartenburger, 施密特, Schwintowski, & 狂野的召唤者,
2003), neither of which consistently involve nonmoral
social processes. 因此, activations that appear
in their respective moral vs. control contrasts may
represent general social processing rather than unique-
ly moral processing. 此外, Greene, Nystrom,
等人. (2004), Heekeren et al. (2003), and Greene,
Sommerville, 等人. (2001) ambiguously asked their sub-
jects to judge whether actions in their moral conditions
were ‘‘appropriate’’ or ‘‘inappropriate.’’ It is unclear
how subjects construed this request (according to their

own moral values, what society deems acceptable, 或者
what is legal), making it difficult to determine whether
the aforementioned study results really reflect the pro-
cesses that underlie moral judgment in particular. 更多的-
超过, the cognitive processing required by previous
control conditions was only weakly matched to that
required by their moral conditions, again making it
difficult to determine which cognitive processes accom-
pany moral judgment in comparison to other kinds of
social judgment.

To avoid possible confounds of past studies, 我们
restricted our moral scenarios to issues of killing and
letting die rather than other moral topics, such as rape,
theft, and lying. Our nonmoral scenarios described
destruction of objects of personal value rather than
harm to other people. 因此, although our nonmoral
scenarios involved other people (such as firefighters and
clerks) and drew upon other kinds of social processing,
judgments or
they did not require any core moral
specifically moral processing. All variables of the facto-
rial design were matched so that nonmoral scenarios
had the same combinations of consequence, 行动,
意图, and language conditions as moral scenarios.
Moral scenarios were then compared directly to non-
moral scenarios, rather than to a baseline or a separate
less demanding cognitive condition. Instead of asking
the subjects whether it would be appropriate to per-
form an action, we asked ‘‘Is it wrong to (action ap-
propriate to the scenario)?’’ and ‘‘Would you (行动
appropriate to the scenario)?’’ By asking both questions,
we hoped to reduce the risk that different subjects
would approach the scenarios with different questions
in mind.

方法

Experimental Design

The factors described in the introduction were opera-
tionalized into four variables (道德, 类型, 方法, 和
语言; 桌子 1) and entered into a factorial design
(桌子 2).

‘‘numerical consequences,’’

The morality variable had two levels: ‘‘Moral’’ scenar-
ios described harm to people, and ‘‘nonmoral’’ scenar-
ios described harm to objects of personal value. 因此,
only moral scenarios asked for core moral judgments as
defined in the Introduction. The type variable had three
‘‘action,’’ and
级别:
‘‘both.’’ ‘‘Numerical consequences’’ scenarios described
an action that would harm a smaller number of people/
objects and another action that would harm a larger
number of people/objects. Because it would be nonsen-
sical to offer separate options describing two different
inactions, options in numerical consequences scenarios
were presented as positive actions. More harmful op-
tions represented violations of Consequentialism (阿尔-
though consequentialists take into consideration many

Schaich Borg et al.

805

D
哦
w
n
我
哦
A
d
e
d

F
r
哦
米

我

/
j

F
/

t
t

我
t
.

:
/
/

/
j

哦
n

1
8

中号
A
y

2
0
2
1

桌子 1. Experimental Variables

Variable

等级

描述

Morality

Moral

Acting on people (例如, trolley

scenario)

Nonmoral

Acting on objects and

possessions

Type

Numerical

结果

行动

两个都 (numerical
结果
+ 行动)

Harming x people/objects vs.
harming y people/objects
(Consequentialism)

Harming x people/objects vs.
letting x people/objects be
harmed (DDA)

Harming x people/objects vs.
letting y people/objects be
harmed (Consequentialism
(西德:1) DDA)

方法

Intentionally using some

people/objects as a means
to save others (DDE)

Nonmeans

Causing unintentional but

语言

Colorful

foreseen harm to people/
things to save others

Described with more detailed
imagery and dramatic words

清楚的

Described with plain imagery

and simple words

DDA = Doctrine of Doing and Allowing; DDE = Doctrine of Double
Effect.

effects other than the number harmed). ‘‘Action’’ sce-
narios then described an action that would harm the
same number (but a different group) of people/objects
as would be harmed if the act were omitted. 行动
scenarios, 所以, proposed violations of the DDA.
‘‘Both’’ scenarios described an action that would harm
fewer people than would be harmed if the act were
omitted, thus portraying conflicts between the DDA and
Consequentialism. If numerical consequences and ac-
tion had been separated into independent two-level
变量, one of their interactions would have been a
cell describing two options of action that saved/killed

桌子 2. Experimental Design

the same number of people. Given that all parties in the
scenarios were anonymous and that all other variables
were held constant, subjects would have had to choose
arbitrarily. Because we would have had no way to
control for the influences on such arbitrary choices
and because the motivations behind such choices would
likely involve nonmoral processing, we combined the
numerical consequences and action variables into the
three-level variable, ‘‘type.’’

The means variable had two levels: ‘‘means’’ scenar-
ios, which described intended harm, and ‘‘nonmeans’’
scenarios, which described foreseen but unintended
伤害. Means scenarios proposed violations of the DDE.
The language variable also had two levels: ‘‘Colorful’’
scenarios were described in dramatic language, 和
‘‘plain’’ scenarios were described in muted language.

Our four variables together constituted a 2 (Morality) (西德:1)
3 (Type) (西德:1) 2 (方法) (西德:1) 2 (语言) 设计 (桌子 2).
Due to timing constraints, we had two scenarios in each
of the moral factor cells (24 moral scenarios) 和一个
scenario in each of the nonmoral factor cells (12 nonmoral
scenarios).

Each scenario block consisted of a series of three
screens (数字 1). The first screen described the sce-
成员. The second and third screens posed the questions
‘‘Is it wrong to (action appropriate to the scenario)?’’
and ‘‘Would you (action appropriate to the scenario)?’’,
which were presented in randomized order. Subjects
read and responded to the scenarios at their own pace,
pressing the right button to answer ‘‘yes’’ and the left
button to answer ‘‘no.’’ Each response advanced the
stimulus program to the next screen. Subjects’ re-
sponses and response times to both questions were
记录的. Four runs of nine fully randomized scenario
blocks were presented with 30 sec of rest at the begin-
ning and at the end of each run. A presentation soft-
器皿 (http://nbs.neuro-bs.com) was used for presenting
all stimuli and for recording responses and response
次.

Subjects were informed of the provocative nature of
the scenarios before entering the scanner. They were
also told that they would have to answer the questions
‘‘Is it wrong to (action appropriate to the scenario)?’’
and ‘‘Would you (action appropriate to the scenario)?’’
after each scenario, so that they would understand the

Variable

Morality

Type

Factorial Design

Moral

Nonmoral

Numerical
结果

行动

两个都

Numerical
结果

行动

两个都

方法

Means Nonmeans Means Nonmeans Means Nonmeans Means Nonmeans Means Nonmeans Means Nonmeans

Language P C

磷

P C

磷

P C

磷

P C

磷

P C

磷

P C

磷

806

认知神经科学杂志

体积 18, 数字 5

D
哦
w
n
我
哦
A
d
e
d

F
r
哦
米

我

/
j

t
t

F
/

我
t
.

:
/
/

/
j

哦
n

1
8

中号
A
y

2
0
2
1

There is no other way to prevent damage to both
pieces of your property. Is it wrong to burn the
2-acre firebreak in your wildflower land? Would
you burn the 2-acre firebreak in your wildflower
土地?

The scenarios were standardized for length and se-
mantic complexity. All scenarios were scored for content
with respect to the experimental variables by three
independent evaluators who had been given prior train-
ing in the meaning of the experimental variables used.
With one exception by one evaluator, all scenarios were
placed in the intended cell of the factorial design by all
three evaluators. In a parallel behavioral study of 51
subjects (results to be discussed in another article), 全部
变量 (道德, 类型, 方法, 和语言) 证实
to have significant effects ( p < .05 to p < .0001) on subject responses and/or response times. Subjects Ethics approval for the study was obtained through the Dartmouth College Committee for Protection of Human Subjects (Hanover, NH, USA). Twenty-eight participants (16 men, 12 women) were recruited from the local Dartmouth College community. One participant’s data were discarded due to technical difficulties and/or data corruption, and three participants’ data were discarded because these subjects took too much time to complete the experiment. The remaining 24 participants (13 men, 11 women) were included in the analysis. The mean age of the subjects was 22.9 years, and ages ranged from 18 to 32 years. All subjects were right-handed on self-report. Imaging Blood-oxygen-level-dependent (BOLD) functional imag- ing was obtained with an ultrafast echo planar gra- dient imaging sequence: TR = 2.5 sec, TE = 35 sec, flip angle = 908, twenty-five 4.5-mm interleaved slices separated by a 1-mm gap per TR, in-plane resolution = 3.125 (cid:1) 3.125 mm, BOLD images tilted 158 clockwise from the AC–PC plane. A typical run was about 9 min long. A set of corresponding anatomical images was obtained with a T1-weighted axial fast-spin echo se- quence, with 25 contiguous slices coplanar to BOLD images, slice thickness = 4.5 mm, gap = 1.0 mm, TE = min full, TR = 650 msec, echo train = 2, field of view = 24 cm. In addition, high-resolution (0.94 (cid:1) 0.94 (cid:1) 1.2 mm) whole-brain 3-D spoiled gradient recall acqui- sition (SPGR) structural images were collected. All im- ages were obtained with a 1.5-T General Electric Horizon whole-body MRI scanner, using a standard birdcage headcoil (GE, Milwaukee, WI). Schaich Borg et al. 807 Figure 1. fMRI functional run. difference between the two types of questions before the scans were collected. Stimuli We developed 36 scenarios to fit into the 2 (cid:1) 3 (cid:1) 2 (cid:1) 2 factorial design representing the variables morality, type, means, and language, respectively. The moral scenarios described variations of moral dilemmas fre- literature quently discussed in moral philosophical (much of which are collected in Fischer & Ravizza, 1992). A full list of the experimental scenarios can be found at http://dbic.dartmouth.edu/~borg. Some exam- ples are as follows: Moral/action/nonmeans/plain language: You find yourself locked in a room in front of a one-way mirror. On the other side of the mirror, there is a machine holding six people, three on each side. A sign on the floor says that if you do nothing, in 10 sec, the three people on the left will be shot and killed and the three people on the right will live. If you push the button in front of you, in 10 sec, the three people on the right will be shot and killed, but the three people on the left will live. There is no way to prevent the deaths of both groups of people. Is it wrong to push the button so that the three people on the right will be shot? Would you push the button so that the three people on the right will be shot? Nonmoral/both/means/colorful language: The extremely hot and parching weather has started a roaring brush fire next to your property, which has been painstakingly sown with wildflowers. If you do nothing, the emergency team will come in their yellow fireproof suits to put out the fire with water—5 acres of your land will be charred to the ground before the fire is extinguished. If you purposely burn down two acres of your wildflower land at the edge of your property in a safe controlled manner as a firebreak, the fire will put itself out when it reaches your property boundaries without destroying any more of your wildflower land. D o w n l o a d e d f r o m l l / / / / / j f / t t i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j f . . t . . . o n 1 8 M a y 2 0 2 1 Preprocessing was performed using SPM99 software (http://www.fil.ion.ucl.ac.uk/spm). Functional and structural images were coregistered and transformed into a standardized reference template from the Montreal Neurological Institute (Montreal, Quebec, Canada). The final voxel size was 3 (cid:1) 3 (cid:1) 3 mm3, and a 10-mm smoothing kernel was applied to the data. Group Statistical Analysis All group analyses were performed using custom- designed programs in MATLAB (The Mathworks, Natick, MA; version 6.0.3). To maximize the detection of com- monly activated regions, we entered raw signal intensity values into the group analyses without any individual subject or omnibus statistical thresholding. Instead, a custom-made mask defined by the mean of all functional scans across subjects was applied to restrict statistical analysis to only those voxels where data were consist- ently present in the group. Before being entered, the data of each voxel were globally normalized across time to remove variance associated with scanner differences from subject to subject. Normalized image volumes associated with reading and responding (from the mo- ment they started reading the scenario to the moment they answered the second ‘‘Is it wrong to (action ap- propriate to the scenario)?’’ or ‘‘Would you (action ap- propriate to the scenario)?’’ question) to scenarios in each analysis of variance (ANOVA) cell were averaged to reduce within-trial variability. Event times were offset by 5 sec to account for hemodynamic response function. The consolidated globally normalized signal temporally adjusted for hemodynamic delay was subsequently en- tered into a 2 (cid:1) 3 (cid:1) 2 (cid:1) 2 mixed-effects ANOVA, with experimental variables entered as fixed effects and with subjects entered as random effect. Significant regions of interest were defined as clusters of 10 voxels or more with F values of p < .05. Because the regions iden- tified were consistent with a priori predictions of sites engaged in moral reasoning, as defined by prior studies (Greene & Haidt, 2002), correction for multiple compar- isons over the entire brain volume was not performed. Significant sites were superimposed on a high-resolution scan from one of the subjects for anatomic visualization. Each site was localized with respect to the anterior com- missure and converted to Talairach coordinates using the Talairach demon (Talairach & Tournoux, 1988). RESULTS AND DISCUSSION Response choice (Table 3), reaction time data (Table 3), and imaging results (representing brain activity during the reading and response phases combined; Table 4) confirm that Consequentialism, the DDA, the DDE, and language affected the responses of our fMRI subject population. Brain and relevant behavioral data will be discussed for the main effect of morality and for each variable, respectively. Main Effect of Morality Manipulation of morality was successful in modulating subjects’ responses to scenarios that were equal in respect to all other experimental variables. Subjects’ choices indicated that they were more willing to act upon objects of personal value than to act upon people, irrespective of resulting consequences or motivating intentions of the act, and irrespective of the language used to describe the act (see Table 3 for specific behavioral data). Nevertheless, reaction times to the question ‘‘Is it wrong to do it?’’ did not differ signifi- cantly ( p = .35) between the moral and the nonmoral conditions, suggesting that the two conditions were well-matched for complexity and difficulty. Subjects answered ‘‘Would you do it?’’ more quickly in moral scenarios than in nonmoral scenarios ( p = .002) how- ever, suggesting that decisions about what to do are processed differently than judgments about what it is wrong to do. This indicates that future studies of morality should distinguish between the two questions. We predicted that the medial frontal gyrus (BA 10), lobe frontal pole (BA 10), and STS/inferior parietal (BA 39) should be more activated in moral scenarios than in nonmoral scenarios, even after adjusting for the variance of Type, Means, and Language. The medial frontal gyrus (rostral gyrus, 105 voxels, BA 10) was activated more in moral scenarios than in nonmoral scenarios (Table 4, Figure 2), supporting our first hy- pothesis. The local maximum observed in this study is more ventral than the local maximum reported by Heekeren et al. (2003), Greene, Sommerville, et al. (2001), or Moll, Eslinger, and Oliveira-Souza, (2001), but the region is bilateral and extends dorsally to the areas reported by previous studies. The medial frontal gyrus is also reliably activated in self-referential process- ing ( Johnson et al., 2002; Kelley et al., 2002). One previous paradigm investigating morality used a con- trol condition that necessitated reference to the self (Greene, Nystrom, et al., 2004; Greene, Sommerville, et al., 2001). Our results suggest that moral judgment may utilize more self-referential processing than even important judgment about one’s possessions or liveli- hood, consistent with the idea that we consider our morals to be crucially defining parts of who we are and who we want to be. Our second hypothesis was also substantiated. We identified a frontopolar region (BA 10) in the left hemisphere that was more active in moral scenarios than in nonmoral scenarios (Table 4, Figure 2), replicat- ing the results of Moll, Eslinger, et al. (2001), but not those of Greene, Nystrom, et al. (2004), Heekeren et al. (2003), or Greene, Sommerville, et al. (2001). The 808 Journal of Cognitive Neuroscience Volume 18, Number 5 D o w n l o a d e d f r o m l l / / / / / j t t f / i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . . f t . . . o n 1 8 M a y 2 0 2 1 Table 3. Behavioral Data Variable Moral Type Means Language % Yes, WRT % Yes, WOY Factorial Design Numerical consequences Action Both Means Nonmeans Means Nonmeans Means Nonmeans P 73 38 C 65 33 P 44 63 C 52 63 P 69 8 C 75 8 P 65 13 C 73 8 P 63 40 C 88 13 P 67 46 C 79 25 RT (sec), WRT 2.54 ± 3.03 2.17 ± 2.33 2.41 ± 2.02 2.60 ± 2.38 1.81 ± 1.47 2.24 ± 2.44 2.35 ± 3.35 2.02 ± 1.81 2.02 ± 1.58 1.73 ± 1.55 2.49 ± 2.40 1.83 ± 1.67 RT (sec), WOY 2.21 ± 1.88 1.74 ± 1.50 2.27 ± 2.92 2.55 ± 2.38 1.67 ± 1.63 1.61 ± 1.60 1.71 ± 1.48 1.55 ± .97 2.14 ± 1.20 2.53 ± 3.48 2.44 ± 2.67 2.22 ± 2.34 Nonmoral Type Means Language % Yes, WRT % Yes, WOY Numerical consequences Action Both Means Nonmeans Means Nonmeans Means Nonmeans P 4 92 C 8 92 P 4 88 C 8 92 P 13 54 C 54 54 P 17 8 C 8 54 P 13 92 C 17 88 P 21 83 C 13 88 RT (sec), WRT 1.48 ± 1.08 1.40 ± 2.28 2.76 ± 3.02 2.61 ± 2.00 2.23 ± 2.76 4.24 ± 3.30 2.99 ± 2.81 2.22 ± 2.27 1.35 ± .79 1.37 ± 2.39 2.62 ± 2.34 2.61 ± 1.80 RT (sec), WOY 1.27 ± .68 1.37 ± 2.61 2.03 ± 3.61 3.75 ± 3.72 4.09 ± 3.28 3.34 ± 1.99 4.93 ± 3.91 3.12 ± 4.17 1.86 ± 1.66 1.44 ± 4.05 2.42 ± 1.91 2.28 ± 2.10 Percentages of yes responses and mean reaction time to the questions ‘‘Is it wrong to do it?’’ (WRT) and ‘‘Would you do it?’’ (WOY) for each cell of the experimental design are presented. S c h a i c h B o r g e t a l . 8 0 9 D o w n l o a d e d f r o m l l / / / / / j f / t t i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . t . . f . . o n 1 8 M a y 2 0 2 1 Table 4. fMRI Data Region Moral > nonmoral

Bilateral inferior/superior rostral

L frontal pole

L lingual gyrus

R temporal–occipital transition zone, pSTS

L temporal–occipital transition zone, pSTS

L supramarginal gyrus

L middle frontal, caudal DLPFC

Nonmoral > moral

R middle frontal gyrus, caudal DLPFC

L medial superior frontal gyrus

Morality (西德:1) Type

L middle temporal gyrus

L lateral orbital frontal gyrus

R middle frontal gyrus, rostral DLPFC

L middle occipital gyrus

L posterior inferior temporal gyrus

L supramarginal gyrus

R supramarginal gyrus

L angular gyrus

R central sulcus

Bilateral medial superior frontal gyri, SMA

Morality (西德:1) 方法

Brodmann’s
Area

19/39

9/46

R anterior superior temporal sulcus, 超导系统

21/22

L inferior rostral gyrus

R frontal pole

R calcerine sulcus

R superior occipital gyrus

R supramarginal gyrus

R angular gyrus

Medial SMA

Morality (西德:1) 语言

R entorhinal/fusiform gyrus

36/20

R posterior orbital frontal gyrus

R lateral temporal pole

Anterior cingulate cortex

R superior rostral gyrus

R transverse temporal sulcus

R superior frontal, DLPFC

(西德:2)12

(西德:2)15

(西德:2)6

(西德:2)54

(西德:2)63

(西德:2)42

(西德:2)3

(西德:2)57

(西德:2)27

(西德:2)48

(西德:2)60

(西德:2)39

(西德:2)6

(西德:2)3

MNI

(西德:2)72

(西德:2)75

(西德:2)72

(西德:2)51

(西德:2)84

(西德:2)63

(西德:2)33

(西德:2)24

(西德:2)78

(西德:2)15

(西德:2)9

(西德:2)81

(西德:2)99

(西德:2)45

(西德:2)63

(西德:2)15

(西德:2)24

(西德:2)12

(西德:2)9

(西德:2)6

(西德:2)3

(西德:2)33

(西德:2)12

(西德:2)6

(西德:2)18

(西德:2)15

(西德:2)9

(西德:2)30

(西德:2)12

(西德:2)3

105

149

491

274

11.65

8.23

6.89

14.22

11.82

4.39

5.78

5.82

5.69

5.75

4.98

8.6

4.55

4.24

6.83

6.6

3.63

4.74

8.53

6.94

8.47

10.01

5.27

11.08

6.83

5.11

6.65

9.81

12.77

5.67

7.76

9.22

7.41

13.9

The Brodmann’s Areas, MNI coordinates, number of voxels (k), and F value of each region of interest according to the interaction in which they
appeared ( p < .05) are presented. Reported coordinates and F values are for the cluster maxima. L = left; R = right. 810 Journal of Cognitive Neuroscience Volume 18, Number 5 D o w n l o a d e d f r o m l l / / / / / j f / t t i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . . t . f . . o n 1 8 M a y 2 0 2 1 frontal pole has also been implicated in moral processing through lesion studies. In fact, among all prefrontal pa- tients, those with frontopolar lesions are often the most problematic and the most difficult to treat for socio- pathic symptoms (Eslinger, Flaherty-Craig, & Benton, 2004). Some argue that sociopathic problems arise be- cause one of the functions of the frontal pole is to main- tain long-term goals while more immediate goals are being processed (Braver & Bongiolatti, 2002; Koechlin, Basso, Pietrini, Panzer, & Grafman, 1999). Mutual coop- eration and altruism often require that individual moral and social decisions be made according to overarching abstract objectives, rather than immediate goals. Thus, if patients are unable to maintain and act according to these long-term goals, it is likely that they will demonstrate impaired sociomoral behavior. Another implication of this possible function of the frontal pole is that moral situations requiring the maintenance and/or comparison of multiple social goals may enlist the frontal pole more than other less discordant situations referencing fewer social goals. We presented moral dilemmas that called upon competing moral intuitions and that sometimes had no clear resolution. In contrast, Heekeren et al. used moral stimuli that are explicitly designed to be simple and easy (presumably requiring less maintenance and manip- ulation of competing intuitions and goals), and many of the stimuli of Greene, Nystrom, et al. and Greene, Sommerville, et al. were very easy to respond to as well (as delineated in the ‘‘easy’’ vs. ‘‘difficult’’ contrast in 2004). If the presented hypothesis of frontal pole func- tion is correct, then this may explain why these fMRI studies did not find the frontal pole to be more active in moral decision making than in control tasks. Supporting our third hypothesis, we found bilateral activation of the posterior STS/inferior parietal lobe (BA 19/39) in the main effect of morality (Table 4, Fig- ure 2). Heekeren et al. (2003) and Moll, de Oliveira- Souza, Bramati, et al. (2002) found areas of BA 39 in the right and left hemispheres, respectively, to be active in their moral conditions; our activation was about 1.5 cm posterior of their reported regions. Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001) found the posterior STS (BA 39) to be more active in per- sonal moral scenarios than in impersonal moral scenar- ios. In contrast, anterior regions of the STS (BA 21/22) were identified only in the Morality (cid:1) Means interaction, and not in the main effect of morality (inconsistent with the results of Heekeren et al., 2003; Moll, de Oliveira- Souza, Bramati, et al., 2002; Moll, de Oliviera-Souza, Eslinger, Bramati, et al., 2002). The posterior STS (BA 19/39), a visual and auditory inte- gration area implicated in analogy tasks (Assaf et al., in press) and other aspects of language requiring audi- tory short-term memory (Dronkers, Wilkins, Van Valin, Redfern, & Jaeger, 2004), has been shown to be function- ally distinct from the anterior STS, which seems to be ac- tive in more automatic linguistic tasks, such as syntax detection, and is specialized to just one sensory modality (Beauchamp, Lee, Argall, & Martin, 2004). There is also evidence that the anterior STS, but not the posterior STS, is active during belief-laden reasoning (Goel & Dolan, 2003). It is likely that the posterior STS plays a corre- spondingly distinct role in moral processing. Accordingly, Greene, Nystrom, et al. (2004) found the posterior STS to be preferentially active in difficult personal scenarios, whereas the anterior STS was preferentially active in easy personal scenarios. One possible explanation for the ob- served activation in many regions of the STS along the anterior–posterior continuum is that the posterior STS may play a preferential role in thought-provoking first- time moral judgment that requires executive resources, whereas the anterior STS may be more involved in previ- ously resolved routine moral judgment that requires more semantically based representational knowledge. More in- vestigation is needed to determine the roles of STS re- gions in the current paradigm, but we underline the need for future studies to distinguish between the functions of the anterior and the posterior STS in moral judgment. Not addressed in our experimental hypotheses, a region of the left rostral dorsolateral prefrontal cortex (DLPFC; BA 9/46) associated with high-level executive function and ‘‘active retrieval’’ in working memory (Kostopoulos & Petrides, 2003; Miller & Cohen, 2001), which is also activated during the moral conditions used by Heekeren et al. (2003) and Moll, Eslinger, et al. (2001), was found to be more active in moral judgment than in nonmoral judgment once all vari- ances associated with other experimental variables have been accounted for. However, the right DLPFC was more active in nonmoral processing than in moral pro- cessing, as it was in the impersonal moral and non- moral scenarios of Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001). The left and right DLPFC regions identified in moral and nonmoral deci- sion making, respectively, had a similar magnitude of response, as assessed by local peak F values. We spec- ulate, therefore, that moral and nonmoral scenarios required equal amounts of working memory and exec- utive cognitive function, but that they required different types of working memory and executive cognitive func- tion determined by the methods used to answer and/or process the experimental questions. It has been sug- gested that the left DLPFC is primarily responsible for working memory and cognitive processes involved in verbal reasoning, whereas the right DLPFC is more responsible for working memory and cognitive process- es involved in spatial and other forms of nonverbal reasoning (Suchan et al., 2002; Caplan & Dapretto, 2001; Chee, O’Craven, Bergida, Rosen, & Savoy, 1999). The left, but not the right, DLPFC is consistently acti- vated in semantic association tasks requiring subjects to judge whether two words are associated or are in the same category (Assaf et al., in press). In fact, repeti- tive transcranial magnetic stimulation (TMS) of the left Schaich Borg et al. 811 D o w n l o a d e d f r o m l l / / / / / j f / t t i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . . . . . f t o n 1 8 M a y 2 0 2 1 experimental interactions, despite the use of complex and provoking moral scenarios. These results suggest that posterior cingulate activation associated with the personal stimuli used by Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001) is not elicited merely by scenario complexity or general emotional conflict. Unlike stimuli used in other studies of morality, the moral personal scenarios of Greene, Nystrom, et al. and Greene, Sommerville, et al. often referenced imme- diate family members or close friends. Thus, although it is possible that the posterior cingulate becomes prefer- entially involved in moral reasoning when the situation under consideration involves one’s loved ones, this D o w n l o a d e d f r o m l l / / / / / j f / t t i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j f . . . . . t o n 1 8 M a y 2 0 2 1 Figure 3. Morality (cid:1) Type interaction. (A) F values ( p < .05) from the mixed-effects ANOVA are shown on a mean high-resolution anatomical T1 image of all 24 subjects. (B) Differences in signal between moral and nonmoral scenarios of numerical consequences, action, and both conditions. A = Middle temporal gyrus (BA 38); B = lateral orbital frontal gyrus (BA 11); C = left middle occipital gyrus (BA 18); D = posterior inferior temporal sulcus (BA 37); E = right supramarginal gyrus (BA 40); F = left supramarginal gyrus (BA 40); G = middle frontal gyrus (BA 8); H = left angular gyrus (BA 40); I = right central sulcus, rostral DLPFC (BA 4); J = bilateral medial superior frontal (BA 6). Figure 2. Main effect of morality. F values ( p < .05) from the mixed-effects ANOVA are shown on a mean high-resolution anatomical T1 image of all 24 subjects in neurological convention. Regions in red were activated more in moral scenarios than in nonmoral scenarios; regions in blue were activated more in nonmoral scenarios than in moral scenarios. DLPFC has been shown to speed up analogic reason- ing without affecting accuracy, whereas the TMS of the right DLPFC had no effect (Boroojerdi et al., 2001). Given such research, it seems reasonable to surmise that subjects in the current study talked through deci- sions to moral questions in their heads and—perhaps, if our interpretation of our posterior STS activation is correct—tried to match aspects of difficult novel sce- narios to heuristics and/or easy previously addressed scenarios for which they had answers. Nonmoral sce- narios did not elicit as much dissonance and, therefore, generally utilized spatial, rather than verbally mediated, problem solving. Some brain regions associated with moral conditions of previous fMRI morality studies were not implicated in the present study. In particular, the posterior cingulate (BA 31), an area associated with emotion (Maddock, 1999) that has been shown to be active during personal moral judgments (Greene, Nystrom, et al., 2004; Greene, Sommerville, et al., 2001) but not during simple moral judgments (Heekeren et al., 2003) or moral judgments compared to unpleasant (as opposed to neutral) non- moral stimuli (Moll, de Oliviera-Souza, Bramati, et al., 2002), did not appear in the main effect of morality or in 812 Journal of Cognitive Neuroscience Volume 18, Number 5 study and past studies suggest that the posterior cingu- late is not preferentially activated by all deontological or emotional moral processings. Past studies have also implicated two regions of the paralimbic system—the amygdala (Greene, Nystrom, et al., 2004) and the temporal pole (Heekeren et al., 2003; Moll, Eslinger, et al., 2001)—in moral judgment, but these regions were not more active in moral scenar- ios than in nonmoral scenarios once numerical conse- quences, action, means, and language have been taken into account (although the temporal pole appeared in morality interactions). Experimental Factors Type Variable: Consequences and Doing vs. Allowing Consequentialism claims that moral decisions should be made to maximize overall consequences (defined as number of lives in this study). The DDA, in contrast, states that it takes more to justify performing an action that results in harm than to justify refraining from an action, thereby allowing harm to occur. Consequential- ism and the DDA thus prescribe that different factors should affect moral judgments. These factors did affect our subjects’ answers (Table 3). In response to the question ‘‘Would you (action appropriate to the scenar- io)?’’, subjects said that they would perform the action resulting in a certain number of deaths over the inaction resulting in the same number of deaths only 9% of the time in moral/action scenarios. In contrast, when inac- tion resulted in worse overall consequences than action in moral/both scenarios, the percentage of responses choosing action over the inaction rose to 31%. When both presented options required action in moral/numer- ical consequence scenarios, subjects chose the best consequences 49% of the time. Furthermore, these percentages represent the number of indicated choices, irrespective of considerations of intentional harm or colorful language that also affect subject choice. Thus, subjects chose not to act in most moral scenarios, as the DDA would oblige, but they were also more likely to forego their preference for inaction if action resulted in in accordance with Consequen- better consequences, tialism. As reflected by their answers to the question ‘‘Is it wrong to (action appropriate to the scenario)?’’, sub- jects’ decisions about which act (or failure to act) was wrong in a moral situation followed a pattern similar to that of their decisions about what they would do, but the pattern was no more pronounced in moral scenarios than in nonmoral scenarios, so the pattern was signifi- cant in the main effect of Type, but not in the Morality (cid:1) Type interaction. The distinctions made by the DDA and Consequential- ism also affected subjects’ response times (see Table 3). Most notably, if reaction time is interpreted as deliber- it can be ation time (Greene, Nytsrom, et al., 2004), inferred that it required less deliberation for subjects to answer ‘‘Would you do it?’’ when both alternatives within a scenario had the same consequences than when the alternatives’ consequences were different. Distinct patterns of brain activity (Figure 3) were associated with each of the three levels of moral/type scenarios—consequences, action, and both—consistent with subjects’ varying responses and response times and partially consistent with our fourth hypothesis. Imaging data suggest that moral consideration of the action-vs.- inaction distinction is mediated primarily by areas of the brain that are traditionally associated with cognition rather than with emotion. Moral/action scenarios prefer- entially activated a large region (491 voxels) of the right middle frontal gyrus, rostral DLPFC (BA 8, Figure 3G), an area implicated in conscious downregulation of negative emotion (Ochsner et al., 2004). Consideration of the action-vs.-inaction distinction also recruited other areas associated with cognitive processing, including BA 18, 37, 40, 4, and 6 (Figure 3C–F, I, and J, respectively), more than nonmoral/action scenarios and more than the over- all mean activation in those regions. On the other hand, the middle temporal gyrus (BA 38, Figure 3A) and a large region (149 voxels) of the medial orbital gyrus (BA 11, Figure 3B)—two paralimbic regions involved in emotion- al reinforcement processing (Rolls, 2004)—were activat- ed much less than in nonmoral/action scenarios and much less than the overall mean activation in those re- gions. Put simply, contrary to our hypothesis, when con- sequences were held constant, moral deliberation about action versus inaction invoked activity in areas dedicated to high-level cognitive processing and suppressed activ- ity in areas associated with socioemotional processing. In contrast to actions and omissions, the cognitive resources used to process numerical consequences in moral scenarios did not diverge much from those elic- ited by nonmoral/numerical consequence scenarios. Moral/numerical consequence scenarios activated the DLPFC (BA 8, Figure 3G) less than nonmoral/numerical consequence scenarios, suggesting that less working memory was required to respond to moral/numerical consequence scenarios than their nonmoral counter- parts. Considering that most people find it strongly preferable to save more lives rather than fewer lives whenever possible, it would be expected that little effort and/or deliberation requiring working memory would be recruited to choose a response in moral scenarios offer- ing options that differed only in their consequences. When lives are not at stake, considerations such as re- quired effort or time are likely to carry more weight and to ultimately contribute to cognitive load, as presumably illustrated in patterns of brain activation associated with nonmoral/numerical consequence scenarios. Singular patterns of brain activity emerge, however, when numerical consequences in moral scenarios con- flict with the desire to refrain from action. Both the or- bital frontal cortex (Figure 3B) and the middle temporal Schaich Borg et al. 813 D o w n l o a d e d f r o m l l / / / / / j t t f / i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . t . . . . f o n 1 8 M a y 2 0 2 1 gyrus (Figure 3A), two areas previously implicated in moral decision making (Heekeren et al., 2003; Moll, de Oliveira-Souza, Bramati, et al., 2002; Moll, de Oliviera- Souza, Eslinger, Bramati, et al., 2002; Moll, Eslinger, et al., 2001), were much more activated in moral/both scenar- ios than in nonmoral/both scenarios and in the mean activation in those regions. Furthermore, the left an- gular gyrus (BA 40, Figure 3H), which is a region im- plicated in number processing (Dehaene, Piazza, Pinel, & Cohen, 2003), and regions of the medial superior frontal gyrus, SMA area (Figure 3J) were much less activated in moral/both scenarios than in nonmoral/ both scenarios or the mean activation in those regions, indicating that areas associated with cognitive processes were less engaged when moral/both scenarios were addressed. Whereas moral/action scenarios called upon explicit cognitive processes, moral/both scenarios were managed by more stimulus-driven emotional processes. These functional imaging results imply that competition between conflicting intuitions attributable to numerical consequences and the DDA exacts more emotional and more automatic processing than either intuition acting alone without incongruity. Thus, the emotional activa- tion that Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001) attributed to personal sce- narios may not be due merely to the action-vs.-inaction distinction or influences of numerical consequences in isolation, but some of the observed activation may be due to the conflict of these, or similar, variables. Means Variable: The DDE Subjects’ responses were affected by whether harm was intended as a means, as forbidden by the DDE, but less dramatically than by the action-vs.-inaction distinction emphasized by the DDA (Table 3). Overall, subjects were more likely to answer that it was wrong to cause a harm intentionally than unintentionally, and to an even greater extent in moral scenarios than in nonmoral scenarios. Similarly, in moral scenarios, subjects’ answers to ‘‘Would you (action appropriate to the scenario)?’’ indicated that they were much less likely to cause harm intentionally than unintentionally. Subjects could deter- mine their typically negative answers more quickly when an option required intentional action over unintentional action, but no more so in moral scenarios than in nonmoral scenarios. Moral processing of intentionally causing harm was characterized by a pattern of brain activity very different from that in the moral processing of action vs. nonac- tion. First, the means variable affected activation in the nonmoral scenarios much more than in the moral scenarios. Second, the pattern of brain activity associat- ed with the means variable in the moral condition resembled the activity that Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001) observed in personal moral scenarios. The greatest activation differences between the moral/means and the moral/ nonmeans conditions appeared as a decrease in activ- ity in the right angular gyrus (BA 40, Figure 4G) and as an increase in activity in anterior regions of the STS (BA 21/22, Figure 4A) and the orbital frontal cortex (BA 11, Figure 4B). The DLPFC was not preferentially activated in moral/means scenarios, such as the foot- bridge case, in contrast to the action condition. In moral/nonmeans scenarios, such as the sidetrack case, D o w n l o a d e d f r o m l l / / / / / j t t f / i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . f . . t . . o n 1 8 M a y 2 0 2 1 Figure 4. Morality (cid:1) Means interaction. (A) F values ( p < .05) from the mixed-effects ANOVA are shown on a mean high-resolution anatomical T1 image of all 24 subjects. (B) Normalized signal for moral/ means and moral/nonmeans conditions. A = anterior STS (BA 21/22); B = medial orbital frontal (BA 11); C = right frontomarginal gyrus (BA 10); D = calcerine sulcus (BA 17); E = right superior occipital gyrus (BA 19); F = right supramarginal gyrus (BA 40); G = right angular gyrus (BA 40); H = right SMA. 814 Journal of Cognitive Neuroscience Volume 18, Number 5 cognitive areas—including the right superior occipital gyrus (BA 19, Figure 4E), right angular gyrus (BA 40, Figure 4G), and SMA (BA 6, Figure 4H)—were prefer- entially activated. These results reveal that moral dilem- mas requiring intentional harm to people elicit more emotional processing, similar to that elicited by the per- sonal moral scenarios of Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001), than moral di- lemmas not requiring intentional harm to people. Such emotional brain activity might be responsible for sub- jects’ tendencies to respond to means scenarios more quickly. The greatest difference between absolute activations in the moral/means and in the moral/nonmeans scenar- ios (rather than between a moral means/nonmeans condition and its respective nonmoral counterpart) was the decrease in activity in the right angular gyrus (BA 40, Figure 4G, p = .035). The right angular gyrus is a complex heteromodal region associated with spatial at- tention and the ability to evaluate one’s sense of agency and sense of responsibility for actions (Farrer et al., 2004; Farrer & Frith, 2002). Given this latter evidence, one can speculate that the difference in activation in this area might be because subjects felt more in control of their decisions and more accountable to their choice when they were making moral decisions that did not require intentional harm to another. Observations made of subjects after finishing the pilot behavioral study and the fMRI study are consistent with this interpretation. Subjects were usually puzzled by their violent reaction towards dilemmas such as the footbridge trolley case and frequently became frustrated in trying to justify their choices towards moral/means scenarios in informal de- briefings after scanning, often resorting to statements such as ‘‘I don’t know, it’s just not right!’’ (see ‘‘moral dumbfounding’’, Haidt, 2001). In contrast, almost all subjects sanguinely reported the use of some form of the DDA in action/both scenarios. The tenacious intui- tion that something was wrong without a corresponding conscious explanation may be responsible for the under- activated angular gyrus in moral/means scenarios (Farrer et al., 2004). Subjects felt like helpless observers—not ‘‘authors’’—of their own passionate aversions to certain types of action requiring intentional harm. Language Variable Language manipulations were very subtle, and their be- havioral effects were correspondingly modest (Table 3). Nevertheless, imaging data corroborate that they had significant effects on multiple regions of the brain after all of the other variables had been taken into account, albeit in patterns not predicted by our experimental hypotheses (Table 4). The data are inconclusive about whether results from past studies are more consistent with scenarios de- scribed in plain language or in colorful language, and no definitive statements can be made about what the brain activity identified in the Morality (cid:1) Language inter- action represents, but it is clear that even very subtle language manipulations affect both moral and nonmoral decision making. The data reported here strongly sug- gest that future imaging studies of morality take care to standardize the amount of dramatic and descriptive language used in both moral and control conditions. Yes/No Responses Emotional processing did not correspond with more yes responses to the question ‘‘Is it wrong to do it?’’ or with more no responses to the question ‘‘Would you do it?’’ More people said that it was not wrong to perform the actions presented in the moral/numerical consequence scenarios than the actions in either the moral/action or the moral/both scenarios, yet comparatively, moral/ numerical consequence scenarios elicited only interme- diate amounts of both emotional and cognitive process- ing. Furthermore, more emotional processing was detected in moral/both scenarios than in moral/action scenarios, yet more people responded that they would perform the action offered in moral/both scenarios than in moral/action scenarios. In confirmation, multiple iter- ations of statistical analyses were performed to investi- gate possible correlations between brain activity and subject response choice. No statistically significant rela- tionships were found (similarly to Moll, Oliviera-Souza, Eslinger, Bramati, et al., 2002). Thus, it is likely that the regions identified in Morality (cid:1) Means and Morality (cid:1) Type interactions generally reflect only how the sce- narios were processed, not what subjects’ final judg- ments or decisions would be. Conclusion This study has found that the moral factors that we differ- entiate in our ethical and political lives—consequences, action, and intention—are also differentiated by the brain processes required to make them. Our data are consistent with the possibility that separate heuristics and brain systems underlie use of the doctrines of Con- sequentialism, Doing and Allowing, and Double Effect. In contrast to the speculations of Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001), our data suggest that some deontological responses (such as the DDA-implied intuition to refrain from action) can be mediated by reason (as suggested by Kant and, more recently, by Hauser), whereas other deontological re- sponses (such as the DDE-implied intuition to refrain from intentional harm) can be mediated by emotion (as suggested by Hume and, more recently, by Haidt). Indi- viduals will utilize varying combinations of cognitive and emotive facilities to address moral challenges, but, over- all, certain types of moral scenarios are likely to be Schaich Borg et al. 815 D o w n l o a d e d f r o m l l / / / / / j t t f / i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . . . f . t . o n 1 8 M a y 2 0 2 1 processed in characteristic ways. Cognitive processing was associated with moral scenarios requiring a choice between a harmful action to lessen an existing threat and an inaction. The emotional patterns of brain activa- tion isolated by Greene, Nystrom, et al. (2004) and Greene, Sommerville, et al. (2001) were primarily associ- ated with dilemmas using people as a means to save others. We demonstrated that emotional systems also become enlisted when the intuition to avoid the cre- ation of a threat and the intuition to minimize harm are aroused simultaneously. Still, emotional activation in the paralimbic system is not associated with an increased frequency of judgments that something is morally wrong. Disparate combinations of systems used to resolve moral dilemmas we have identified represent differences only in processing, not differences in judgments or actions. Further research is needed to elucidate the regions of the brain that are truly responsible for the choice to answer ‘‘Yes, it is wrong’’ compared to ‘‘No, it is not wrong.’’ Our data highlight that morality is not represented in one place in the brain, but instead is mediated by multiple networks. Some of these neural networks are modulated by the language in which stimuli are presented; thus, fu- ture studies on morality should control for the level of emotional and/or descriptive details in their stimuli ac- cordingly. Likewise, careful attention needs to be given to the nature of nonmoral control conditions. Furthermore, most published fMRI studies, including this one, are de- signed to map out regions of the brain that are active during specific types of moral decisions. After this im- portant initial groundwork is laid, a next step for moral researchers is to use network modeling methods to de- lineate how the regions of the brain identified in these first fMRI studies cooperate and interact. We want to emphasize that this study was designed to characterize the neural processes involved in responding to moral dilemmas, not to attempt to find answers to how moral dilemmas should be processed or resolved. Study- ing conscious moral deliberation helps identify factors that are also likely to play a role in simple, but important, moral judgments and decisions. The doctrines operation- alized in this study often facilitate our views on topics ranging from social etiquette to controversial issues of abortion or euthanasia. Understanding how these heu- ristics are neurologically represented may help explain why moral convictions vary so greatly, which, in turn, may influence the decisions we make as individuals and the way we understand and judge other cultures. Acknowledgments We thank George Wolford, Roger Norlund, and Tammy Laroche for their helpful contributions to this project. Reprint requests should be sent to Scott T. Grafton, Center for Cognitive Neuroscience, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, or via e-mail: Scott.T.Grafton@ Dartmouth.edu. The data reported in this experiment have been deposited with the fMRI Data Center (www.fmridc.org). The accession number is 2-2006-1211A. REFERENCES Assaf, M., Calhoun, V. D., Kuzu, C. H., Kraut, M. A., Rivkin, P. R., Hart, J., Jr., & Pearlson, G. D. (in press). Neural correlates of the object recall process in semantic memory. Psychiatry Research: Neuroimaging. Baddeley, A. (1986). Working memory. New York: Clarendon Press/Oxford University Press. Beauchamp, M. S., Lee, K. E., Argall, B. D., & Martin, A. (2004). Integration of auditory and visual information about objects in superior temporal sulcus. Neuron, 41, 809–823. Boroojerdi, B., Phipps, M., Kopylev, L., Wharton, C. M., Cohen, L. G., & Grafman, J. (2001). Enhancing analogic reasoning with rTMS over the left prefrontal cortex. Neurology, 56, 526–528. Braver, T. S., & Bongiolatti, S. R. (2002). The role of frontopolar cortex in subgoal processing during working memory. Neuroimage, 15, 523–536. Caplan, R., & Dapretto, M. (2001). Making sense during conversation: An fMRI study. NeuroReport: For Rapid Communication of Neuroscience Research, 12, 3625–3632. Chee, M. W. L., O’Craven, K. M., Bergida, R., Rosen, B. R., & Savoy, R. L. (1999). Auditory and visual word processing studied with fMRI. Human Brain Mapping, 7, 15–28. Damasio, A. R. (1994). Descarte’s error: Emotion, rationality and the human brain. New York: Putnam. Dehaene, S., Piazza, M., Pinel, P., & Cohen, L. (2003). Three parietal circuits for number processing. Cognitive Neuropsychology, 20, 487–506. Dronkers, N. F., Wilkins, D. P., Van Valin, R. D., Jr., Redfern, B. B., & Jaeger, J. J. (2004). Lesion analysis of the brain areas involved in language comprehension. Cognition, 92, 145–177. Eslinger, P. J., Flaherty-Craig, C. V., & Benton, A. L. (2004). Developmental outcomes after early prefrontal cortex damage. Brain and Cognition, 55, 84–403. Farrer, C., Franck, N., Frith, C. D., Decety, J., Georgieff, N., d’Amato, T., & Jeannerod, M. (2004). Neural correlates of action attribution in schizophrenia. Psychiatry Research: Neuroimaging, 131, 31–44. Farrer, C., & Frith, C. D. (2002). Experiencing oneself vs. another person as being the cause of an action: The neural correlates of the experience of agency. Neuroimage, 15, 596–603. Fischer, J. M., & Ravizza, M. (Eds.) (1992). Ethics: Problems and principles. Fort Worth, TX: Harcourt, Brace, and Jovanovich College Publishers. Goel, V., & Dolan, R. J. (2003). Explaining modulation of reasoning by belief. Cognition, 87, B11–B22. Greene, J., & Haidt, J. (2002). How (and where) does moral judgment work? Trends in Cognitive Sciences, 6, 517–523. Greene, J. D., Nystrom, L. E., Engell, A. D., & Darley, J. M. (2004). The neural bases of cognitive conflict and control in moral judgment. Neuron, 44, 389–400. Greene, J. D., Sommerville, R., Nystrom, L. E., Darley, J. M., & Cohen, J. D. (2001). An fMRI investigation of emotional engagement in moral judgment. Science, 293, 2105–2108. Haidt, J. (2001). The emotional dog and its rational tail: A social intuitionist approach to moral judgment. Psychological Review, 108, 814–834. Hauser, M. D. (2006). Moral minds: The unconscious voice of right and wrong. New York: Harper Collins. 816 Journal of Cognitive Neuroscience Volume 18, Number 5 D o w n l o a d e d f r o m l l / / / / / j t t f / i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . . . t . . f o n 1 8 M a y 2 0 2 1 Heekeren, H. R., Wartenburger, I., Schmidt, H., Schwintowski, H.-P., & Villringer, A. (2003). An fMRI study of simple ethical decision-making. NeuroReport: For Rapid Communication of Neuroscience Research, 14, 1215–1219. Howard-Snyder, F. (2002). Doing vs. allowing harm. In E. N. Zalta (Ed.), The Stanford encyclopedia of philosophy. Available at http://plato.stanford.edu/entries/doing-allowing/. Hume, D. (1888). A treatise of human nature. Oxford: Clarendon Press. Johnson, S. C., Baxter, L. C., Wilder, L. S., Pipe, J. G., Heiserman, J. E., & Prigatano, G. P. (2002). Neural correlates of self-reflection. Brain, 125, 1808–1814. Kahneman, D., & Tversky, A. (1982). The psychology of preferences. Scientific American, 246, 160–173. Kant, I. (1959). Foundations of the metaphysics of morals. Indianapolis, IN: Bobbs-Merrill. Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., & Heatherton, T. F. (2002). Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience, 14, 785–794. Koechlin, E., Basso, G., Pietrini, P., Panzer, S., & Grafman, J. (1999). The role of the anterior prefrontal cortex in human cognition. Nature, 399, 148–151. Kostopoulos, P., & Petrides, M. (2003). The mid-ventrolateral prefrontal cortex: Insights into its role in memory retrieval. European Journal of Neuroscience, 17, 1489–1497. Maddock, R. J. (1999). The retrosplenial cortex and emotion: New insights from functional neuroimaging of the human brain. Trends in Neurosciences, 22, 310–316. McIntyre, A. (2004). Doctrine of Double Effect. In E. N. Zalta (Ed.), The Stanford encyclopedia of philosophy. Available at http://plato.stanford.edu/entries/double-effect/. Mesulam, M. M. (2000). Behavioral neuroanatomy: Large-scale networks, association cortex, frontal syndromes, the limbic system, and hemispheric specializations. In M. M. Mesulam (Ed.), Principles of behavioral and cognitive neurology (2nd ed., pp. 1–120). London: Oxford University Press. Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167–202. Moll, J., Eslinger, P. J., & Oliveira-Souza, R. (2001). Frontopolar and anterior temporal cortex activation in a moral judgment task. Arquivos de Neuro-Psiquiatria, 59, 657–664. Moll, J., de Oliveira-Souza, R., Bramati, I. E., & Grafman, J. (2002). Functional networks in emotional moral and nonmoral social judgments. NeuroImage, 16, 696–703. Moll, J., de Oliveira-Souza, R., & Eslinger, P. J. (2003). Morals and the human brain: A working model. Philadelphia, PA: Lippincott Williams & Wilkins. Moll, J., de Oliviera-Souza, R., Eslinger, P. J., Bramati, I. E., Mourao-Miranda, J., Andreiuolo, P. A., & Pessoa, L. (2002). The neural correlates of moral sensitivity: A functional magnetic resonance imaging investigation of basic and moral emotions. Journal of Neuroscience, 22, 2730–2736. Nichols, S. (2004). Sentimental rules: On the natural foundations of moral judgment. New York: Oxford University Press. Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004). For better or for worse: Neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage, 23, 483–499. Rolls, E. T. (2004). The functions of the orbitofrontal cortex. Brain and Cognition, 55, 11–29. Sinnott-Armstrong, W. (2003). Consequentialism. In E. N. Zalta (Ed.), The Stanford encyclopedia of philosophy. Available at http://plato.stanford.edu/entries/consequentialism/. Suchan, B., Yagueez, L., Wunderlich, G., Canavan, A. G. M., Herzog, H., Tellmann, L., Homberg, V., & Seitz, R. J. (2002). Hemispheric dissociation of visual-pattern processing and visual rotation. Behavioural Brain Research, 136, 533–544. Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical Publishers, Inc. D o w n l o a d e d f r o m l l / / / / / j f / t t i t . : / / D h o t w t p n : o / a / d m e i d t f r p o r m c . h s i p l v d e i r r e c c h t . m a i r e . d c u o m o / c j n o a c r t n i c / e a - r p t d i c 1 l 8 e 5 - 8 p 0 d 3 f / 1 1 9 8 3 5 / 8 5 5 / 4 8 0 o 3 c / n 1 2 7 0 5 0 6 6 1 1 8 8 8 / 5 j 8 o 0 c 3 n p . d 2 0 b 0 y 6 g . u 1 e 8 s . t 5 o . n 8 0 0 8 3 S . p e p d f e m b b y e r g 2 u 0 e 2 s 3 t / j . . f . . . t o n 1 8 M a y 2 0 2 1 Schaich Borg et al. 817 Consequences, 行动, and Intention as Factors image

下载pdf