Open Access Series of Imaging Studies: Longitudinal MRI
Data in Nondemented and Demented Older Adults

Daniel S. Marcus1, Anthony F. Fotenos1, John G. Csernansky2,
John C. Morris1, and Randy L. Buckner3,4,5,6

Abstrait

■ The Open Access Series of Imaging Studies is a series of
neuroimaging data sets that are publicly available for study and
analyse. The present MRI data set consists of a longitudinal collec-
tion of 150 subjects aged 60 à 96 years all acquired on the same
scanner using identical sequences. Each subject was scanned
on two or more visits, separated by at least 1 year for a total of
373 imaging sessions. Subjects were characterized using the Clin-
ical Dementia Rating (CDR) as either nondemented or with very
mild to mild Alzheimerʼs disease. Seventy-two of the subjects were
characterized as nondemented throughout the study. Sixty-four
of the included subjects were characterized as demented at the
time of their initial visits and remained so for subsequent scans,
y compris 51 individuals with CDR 0.5 similar level of impairment

to individuals elsewhere considered to have “mild cognitive
impairment.” Another 14 subjects were characterized as non-
demented at the time of their initial visit (CDR 0) and were subse-
quently characterized as demented at a later visit (CDR > 0). Le
subjects were all right-handed and include both men (n = 62) et
femmes (n = 88). For each scanning session, three or four indi-
vidual T1-weighted MRI scans were obtained. Multiple within-
session acquisitions provide extremely high contrast to noise,
making the data amenable to a wide range of analytic approaches
including automated computational analysis. Automated calcula-
tion of whole-brain volume is presented to demonstrate use of
the data for measuring differences associated with normal aging
and Alzheimerʼs disease. ■

INTRODUCTION

The Open Access Series of Imaging Studies (OASIS) is a
project aimed at making neuroimaging data sets of the
brain freely available to the scientific community. By compil-
ing and freely distributing neuroimaging data sets, we hope
to facilitate future discoveries in basic and clinical neuro-
science similar to other initiatives such as the Alzheimerʼs
Disease Neuroimaging Initiative. The initial OASIS set of
cross-sectional MRI data included over 400 demented and
nondemented individuals across the adult lifespan (Marcus,
Wang, et coll., 2007). Here we describe a longitudinal sample of
MRI data from older adults, with and without Alzheimerʼs dis-
ease (AD). The preparation and release of the data set follows
the rigor established with the initial release: careful quality
control, detailed documentation, example of postprocessed
images, full anonymization, multiple access methods, sur-
going support, and liberal data usage requirements (Marcus,
Wang, et coll., 2007).

The data set includes longitudinal MRI data from 150 dans-
dividuals age 60 à 96 années, y compris 64 individuals with
very mild to moderate AD as diagnosed clinically and char-
acterized using the Clinical Dementia Rating (CDR) scale
(Morris et al., 2001; Morris, 1993) at their initial visit. Another

1Washington University School of Medicine, 2Northwestern Uni-
versity School of Medicine, 3Université Harvard, 4Harvard Médical
École, 5Hôpital général du Massachusetts, 6Howard Hughes Medi-
cal Institute

14 of the individuals were characterized as nondemented
at the time of one or more scans and then clinically deter-
mined to have AD at the time of a subsequent scan. All
data were acquired on the same scanner using identical
procedures. Subjects were screened to eliminate indi-
viduals with psychiatric and neurological conditions that
might contribute to dementia but, where possible, variation
typical of advanced aging was included. Ainsi, many of the
older adults had age-related increases in blood pressure
and a small percentage treated diabetes. Sample charac-
teristics were similar between the individuals with and with-
out AD.

Longitudinal brain imaging has proven useful in studying
normal and diseased aging. Whole-brain volume decline
as measured from longitudinally acquired MRI has been
shown to evolve at a near 0.5% per year (in the range −0.37
to −0.88 across seven reports; Fotenos, Snyder, Girton,
Morris, & Buckner, 2005; Jack et al., 2004; Liu et al., 2003;
Resnick, Pham, Kraut, Zonderman, & Davatzikos, 2003;
Thompson et al., 2003; Wang & Doddrell, 2002; Chan
et coll., 2001) in nondemented older adults, somewhat
greater than that observed in younger adults (Raz et al.,
2005; Liu et al., 2003). The volumes of the whole-brain
and structures associated with memory have been shown
to atrophy at a significantly greater rate in mild cognitive im-
pairment and early AD (par exemple., Dickerson et al., 2006; Fotenos
et coll., 2005; Killiany et al., 2000, 2002; Fox & Freeborough,
1997; Jack et al., 1997; Jack, Petersen, OʼBrien, & Tangalos,

© 2010 Massachusetts Institute of Technology

Journal des neurosciences cognitives 22:12, pp. 2677–2684

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1992). Longitudinal analysis of measures derived from
advanced computational methods, including nonlinear
deformations and shape analysis, have also revealed age-
and disease-associated changes in the brain (par exemple., Buckner
et coll., 2005; Thompson et al., 2003; Wang et al., 2003; Scahill,
Schott, Stevens, Rossor, & Fox, 2002). Longitudinal mea-
sures of brain structure are emerging as tools for tracking
progression of disease and as adjunct outcome measures
in clinical trials (par exemple., Jack et al., in press; Borroni, Premi,
Di Luca, & Padovani, 2007; Chong, Lim, & Sahadevan,
2006; Mueller et al., 2005). The OASIS longitudinal data
set is being made openly available to encourage continued
investigation into aging and disease processes and to sup-
port development of improved methods for studying these
processes.

mentia. Each subject was scanned on two or more sep-
arate occasions, with an average delay of 719 jours (range =
183–1707 days) between visits. The final data set includes
150 subjects and 373 imaging sessions.

Portions of the clinical, demographic, and longitudinal
image data obtained from subjects in this release have
been used in previous publications (Dickerson et al., 2008;
Fotenos, Mintun, Snyder, Morris, & Buckner, 2008; Il,
Chen, & Evans, 2008; Salat et al., 2009; Dickerson et al.,
2009; Buckner et al., 2005; Burns et coll., 2005; Fotenos
et coll., 2005; Head, Snyder, Girton, Morris, & Buckner, 2005;
Buckner et al., 2004; Salat et al., 2004). Many of the subjects
were part of the cross-sectional OASIS data set (Marcus,
Olsen, et coll., 2007; Marcus, Wang, et coll., 2007) but have been
assigned new random identifiers.

MÉTHODES

Sujets

Subjects aged 60 à 96 years were selected from a larger
database of individuals who had participated in MRI studies
at Washington University on the basis of the availability of at
least two separate visits in which clinical and MRI data were
obtained, at least three acquired T1-weighted images per
imaging session, and right-hand dominance. Subjects were
obtained from the longitudinal pool of the Washington
University Alzheimer Disease Research Center (ADRC).
The ADRCʼs normal and cognitively impaired subjects were
recruited primarily through media appeals and word of
mouth, avec 80% of subjects initiating contact with the cen-
ter and the remainder being referred by physicians. All
subjects participated in accordance with guidelines of the
Washington University Human Studies Committee. Ap-
proval for public sharing of the anonymized data was also
specifically obtained.

All subjects were screened for inclusion in this release.
Each subject underwent the ADRCʼs full clinical assessment
as described below. Subjects with a primary cause of de-
mentia other than AD (par exemple., vascular dementia, primaire
progressive aphasia), active neurologic or psychiatric ill-
ness (par exemple., major depression), serious head injury, histoire
of clinically meaningful stroke, and use of psychoactive
drugs were excluded, as were subjects with gross anatomi-
cal abnormalities evident in their MRI images (par exemple., grand
lesions, tumors). Cependant, subjects with age-typical brain
changes (par exemple., mild atrophy, leukoaraiosis) were accepted.
MRI acquisitions typically were obtained within 1 year before
or after a subjectʼs clinical assessment (mean = 111 jours,
range = 0–352 days). Twelve subjects with AD were scanned
after a somewhat longer duration (mean = 653 jours, range =
374–924 days) but were included because each had sev-
eral previous clinical assessments with CDR scores greater
que 0. Two subjects without dementia were scanned some-
what longer than 1 year before a clinical assessment (392
et 431 jours) but were included because their subsequent
clinical assessments continued to indicate no signs of de-

Clinical Assessment

Dementia status was established and staged using the CDR
scale. The determination of AD or nondemented control
status is based solely on clinical methods, without refer-
ence to psychometric performance, and any potential alter-
native causes of dementia (known neurological, medical,
or psychiatric disorders) must not contribute to dementia.
The diagnosis of AD is based on clinical information (de-
rived primarily from a collateral source) that the subject
has experienced gradual onset and progression of decline
in memory and other cognitive and functional domains.
Spécifiquement, the CDR is a dementia-staging instrument that
rates subjects for impairment in each of six domains: mem-
ory, orientation, judgment and problem solving, fonction
in community affairs, home and hobbies, and personal
care. On the basis of the collateral source and subject inter-
voir, a global CDR score is derived from individual ratings
in each domain. A global CDR of 0 indicates no dementia
and a CDR of 0.5, 1, 2, et 3 represent very mild, mild, mod-
erate, and severe dementia, respectivement. These methods
allow for the clinical diagnosis of AD in individuals with a
CDR of 0.5 or greater on the basis of standard criteria that
is confirmed by histopathological examination in 93% de
the individuals (Berg et al., 1998), even for those in the
earliest symptomatic stage (CDR 0.5) of AD who else-
where may be considered to represent “mild cognitive
impairment” (Storandt, Grant, Miller, & Morris, 2006).

Image Acquisition

Pour chaque sujet, three to four individual T1-weighted
magnetization prepared rapid gradient-echo (MP-RAGE)
images were acquired on a 1.5-T Vision scanner (Siemens,
Erlangen, Allemagne) in a single imaging session. Head
movement was minimized by cushioning and by a thermo-
plastic face mask. Headphones were provided for commu-
nication. A vitamin E capsule was placed over the left
forehead to provide a reference marker of anatomic side.
Positioning was low in the head coil (toward the feet) à

2678

Journal des neurosciences cognitives

Volume 22, Nombre 12

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optimize imaging of the cerebral cortex. MP-RAGE param-
eters were empirically optimized for gray-white contrast
(Tableau 1). The scanner and the sequences were maintained
across the duration of the study so the present data are not
influenced by hardware upgrades or other instrument
differences.

Postprocessing

Pour chaque sujet, the individual scan files were converted
from Siemens proprietary IMA format into 16-bit NiFTI1
format using a custom conversion program. Header fields
with identifying information (patient ID, experiment date)
were left blank. The images were then corrected for inter-
scan head movement and spatially warped into the atlas
space of Talairach and Tournoux (1988) using a rigid trans-
formation that differs in process from the original piecewise
scaling. The resulting transformation nonetheless places
the brains in the same coordinate system and bounding
box as the original atlas. The template atlas used here con-
sisted of a combined young-and-old target previously gen-
erated from a representative sample of young (n = 12) et
nondemented old (n = 12) adultes. The use of a combined
template has been shown to minimize the potential bias of
an atlas normalization procedure to overexpand atrophied
brains (Buckner et al., 2004). Given the age range of the
present sample, an old-only atlas target could have been
used. We chose to retain the young-and-old target to be com-
parable to our earlier report (Marcus, Wang, et coll., 2007).
For registration, a 12-parameter affine transformation
was computed to minimize the variance between the first
MP-RAGE image and the atlas target. The remaining
MP-RAGE images were registered to the first (in-plane
stretch allowed) and resampled via transform composition
into a 1-mm isotropic image in atlas space. The result was a
single, high-contrast, averaged MP-RAGE image in atlas
espace. Subsequent steps included skull removal by applica-
tion of a loose-fitting atlas mask and correction for intensity
inhomogeneity because of nonuniformity in the magnetic

field. Intensity variation was corrected across contiguous
regions on the basis of a quadratic inhomogeneity model
fitted to data from a phantom.

Estimated Total Intracranial Volume and
Normalized Whole-brain Volume

The procedures used for measuring intracranial and whole-
brain volumes have been described previously (Fotenos
et coll., 2005; Buckner et al., 2004) and are identical to our
earlier OASIS data release (Marcus, Wang, et coll., 2007). Esti-
mated total intracranial volume (eTIV) was computed by
scaling the manually measured intracranial volume of the
atlas by the determinant of the affine transform connecting
each individualʼs brain to the atlas. This method is mini-
mally influenced and proportional to manually measured
total intracranial volume.

Normalized Whole-brain Volume (nWBV) was computed
using the FAST program in the FSL software suite (www.
fmrib.ox.ac.uk/fsl). The image was first segmented to clas-
sify brain tissue as cerebral spinal fluid, gray, or white matter.
The segmentation procedure iteratively assigned voxels to
tissue classes on the basis of maximum likelihood estimates
of a hidden Markov random field model. The model used
spatial proximity to constrain the probability with which
voxels of a given intensity are assigned to each tissue class.
Enfin, nWBV was computed as the proportion of all voxels
within the brain mask classified as tissue (either gray or
white matter). The unit of normalized volume is percent,
which represents the percentage of the total white and
gray matter voxels within the eTIV (Fotenos et al., 2005).
To calculate atrophy rates, we estimated the slope of the
line connecting nWBV measurements within each individ-
double, divided by baseline nWBV, expressed as percent change
per year. Par exemple, in a participant with two scans, atro-
phy rate was computed as nWBV at Scan 2 minus nWBV at
Scan 1, divided by the interval between measurements, di-
vided by nWBV at Scan 1, times 100. ANCOVA was again
used to test for differences in atrophy rate on the basis of
âge, sex, and dementia status.

Tableau 1. MR Image Acquisition Details

Quality Control

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Sequence

TR (msec)

TE (msec)

Flip angle

TI (msec)

TD (msec)

Orientation

Thickness, gap (mm)

Slice number

Resolution

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MP-RAGE

9.7

4.0

10°

20

200

Sagittal

1.25, 0

128

256 × 256 (1 × 1 mm)

All images in the data set were carefully screened for arti-
facts, acquisition problems, and processing errors. During
the screening process, each image was viewed on a per-slice
basis along the axis of acquisition. Typical flaws visible in the
images included electronic noise resulting in bright lines
through multiple slices, motion artifacts appearing as hazy
bands across the image, poor head positioning resulting
in wraparound artifacts, distortions from dental work, et
limited image contrast. Images with severe flaws were ex-
cluded from the data set. A number of borderline images
remain in the distribution, providing tool builders and
testers with a realistic range of acquisition quality. In cases
where individual scans were deemed unusable, the single
scan was removed from the data set but the remainder

Marcus et al.

2679

Tableau 2. Age and Diagnosis Characteristics of Subjects at the Time of Their Initial Visit

Nondemented

Demented

Age Group

60s

70s

80s

90s

N

34

71

41

4

Total

150

n

23

35

26

2

86

Mean

Male

Femelle

Convert

65.71

74.91

84.30

92.50

75.82

6

11

9

0

26

17

24

17

2

59

3

4

7

0

14

n

11

36

15

2

64

Mean

Male

Femelle

CDR 0.5/1

65.67

73.97

82.33

93.00

74.95

8

20

7

1

36

3

16

8

1

29

8/3

29/7

13/2

1/1

52/13

The Convert column indicates individuals who were determined to have AD on a subsequent visit. CDR = Clinical Dementia Rating, avec 0, 0.5, et 1
corresponding to nondemented, very mild, and AD, respectivement. CDR 0.5 individuals may be considered to represent those elsewhere labeled as
“mild cognitive impairment” (MCI).

of the subjectʼs scans was included. Dans l'ensemble, 25 imaging
sessions were excluded from the final release because of
poor image quality.

RÉSULTATS

Overview of the Data Set

The current data set consists of 150 sujets (88 femmes)
âgé 60 à 96 années (Tableau 2). At the time of their initial
visit, 86 had a CDR score of 0, indicating no dementia, et
64 had a CDR score greater than 0 (52 sujets, CDR = 0.5;
13 sujets, CDR = 1; 0 sujet, CDR = 2), indicating a
diagnosis of very mild to moderate AD. Of the subjects
who were initially determined to be nondemented, 14 étaient
later determined to be demented (CDR > 0) at the time of a
subsequent imaging visit. Additional demographics and
clinical characteristics of the subjects are shown in Table 3.

Anatomic Characteristics

Whole-brain volumes for each of the subjects in the data
set are plotted by age at each visit in Figure 1. Marked de-
creases in nWBV are apparent with age, and nWBV is signifi-
cantly impacted by dementia status (Chiffre 2). Differences
in nWBV between nondemented (CDR 0), very mild de-
mentia (CDR 0.5), and mild dementia (CDR 1) are all sig-
nificant ( p < .01). Whole-brain atrophy rates are shown in Figure 3 (top). The atrophy rate in nondemented indi- viduals was −0.49% (SD = 0.56) per year. The atrophy rate in individuals with DAT was −0.87% (SD = 0.99) per year, a significant increase compared with nondemented indi- viduals ( p < .01). For the 14 individuals who declined from an initial CDR 0 to a CDR 0.5 at the time of their last scan, the atrophy rate fell between nondemented indi- viduals and those who entered with AD (−0.69% per year, SD = 0.62). Table 3. Sample Characteristics of Subjects Number Female/male Age (years) Education (years) MMSE Prescriptions (n) Systolic BP (mmHg) Diastolic BP (mmHg) Reported HBP (%) Diabetes (%) CDR 0 86 60/26 75.8 ± 8.2 (60–93) 15.2 ± 2.7 (8–23) 29.1 ± 0.8 (27–30) 2.9 ± 2.1 (0–9) 135.5 ± 20.3 (98–192) 72.8 ± 10.2 (50–100) 54.6 9.3 CDR 0.5 51 21/30 74.8 ± 6.3 (62–90) 13.6 ± 2.8 (6–20) 26 ± 3.1 (17–30) 3.2 ± 2.4 (0–11) CDR 1 13 7/6 75.7 ± 8.7 (61–96) 14.0 ± 3.2 (8–20) 23.0 ± 3.3 (19–30) 2.5 ± 2.4 (0–7) 143.5 ± 19.4 (118–188) 143.4 ± 24.9 (90–188) 77.1 ± 10.1 (58–98) 76.9 ± 9.2 (60–88) 46.0 14.0 53.3 13.3 The sample consisted of 150 individuals (72 nondemented, 64 with AD, and 14 who converted over the course of the study). Clinical measures in the above table were obtained at the clinical assessment closest in date to the initial imaging session, except in 39 cases where these values were not available until a later visit. Values are presented as mean ± SD. Values in parentheses represent the range. Compared with the nondemented adults, the older adults with dementia had lower scores on the MMSE ( p < .001) and slightly fewer years of education ( p < .001). CDR = Clinical Dementia Rating, with 0, 0.5, and 1 corresponding to nondemented, very mild, and mild AD, respectively; MMSE = Mini-Mental State Examination where scores range from 30 (best) to 0 (worst); HBP = high blood pressure. 2680 Journal of Cognitive Neuroscience Volume 22, Number 12 D o w n l o a d e d l l / / / / j t t f / i t . : / / f r o m D h o t w t n p o : a / d / e m d i t f r p o m r c h . s p i l d v i e r e r c c t h . m a i r e . d c u o o m c / n j a o r c t i n c / e a - p r d t i 2 c 2 l e 1 2 - p 2 d 6 f 7 / 7 2 1 2 9 / 4 1 0 2 1 / 7 2 2 6 o 7 c 7 n / 2 1 0 7 0 7 9 0 8 2 4 1 4 8 0 / 7 j o p c d n . b y 2 0 g 0 u 9 e . s t 2 o 1 n 4 0 0 7 8 . S p e d p f e m b y b e r g u 2 0 e 2 s 3 t / j t . . . / f o n 1 8 M a y 2 0 2 1 Figure 1. Longitudinal plot of nWBV; lines connect nWBV at baseline and follow-up scans (or the best fit, for participants with multiple follow-ups), such that the slope of each line as a proportion of baseline nWBV represents an individualʼs atrophy rate. Figure 2. Mean cross-sectional nWBV for all individuals separated by Clinical Dementia Rating (CDR) (0, 0.5, and 1) at the individualsʼ initial visit. All differences are significant. Figure 3. (A) Longitudinal atrophy rates, expressed in nWBV loss per year relative to baseline, are separated by CDR status at first and last session. Atrophy rate was significantly greater for the group entering the experiment with very mild dementia (CDR 0.5 → 0.5/1) than the group entering without dementia that remained stable (CDR 0 → 0), whereas the rate for the group that manifested the earliest signs of AD during the experiment (CDR 0 → 0.5) fell between those with no dementia and those who entered with dementia. (B) Individual atrophy rates plotted by age and CDR score. The trendline is plotted for CDR 0 → 0. D o w n l o a d e d l l / / / / j f / t t i t . : / / f r o m D h o t w t n p o : a / d / e m d i t f r p o m r c h . s p i l d v i e r e r c c t h . m a i r e . d c u o o m c / n j a o r c t i n c / e a - p r d t i 2 c 2 l e 1 2 - p 2 d 6 f 7 / 7 2 1 2 9 / 4 1 0 2 1 / 7 2 2 6 o 7 c 7 n / 2 1 0 7 0 7 9 0 8 2 4 1 4 8 0 / 7 j o p c d n . b y 2 0 g 0 u 9 e . s t 2 o 1 n 4 0 0 7 8 . S p e d p f e m b y b e r g u 2 0 e 2 s 3 t / j . . t f . / o n 1 8 M a y 2 0 2 1 Marcus et al. 2681 Table 4. Measures Included in the Data Set Age Sex Age at time of image acquisition (years) Sex (M or F) Education Years of education SES Socioeconomic status as assessed by the Hollingshead Index of Social Position and classified into categories from 1 (highest status) to 5 (lowest status) (Hollingshead, 1957) MMSE Mini-Mental State Examination score (range is from 0 = worst to 30 = best) (Folstein, Folstein, & McHugh, 1975) CDR ASF eTIV nWBV Clinical Dementia Rating (0 = no dementia, 0.5 = very mild AD, 1 = mild AD, 2 = moderate AD) (Morris, 1993) Atlas scaling factor (unitless). Computed scaling factor that transforms native-space brain and skull to the atlas target (i.e., the determinant of the transform matrix) (Buckner et al., 2004) Estimated total intracranial volume (cm3) (Buckner et al., 2004) Normalized whole-brain volume, expressed as a percent of all voxels in the atlas-masked image that are labeled as gray or white matter by the automated tissue segmentation process (Fotenos et al., 2005) Obtaining and Using the Data OASIS data can be obtained at http://www.oasis-brains.org. Requests for DVD distributions of the data can be submitted at the Web site. For convenience, we also provide the data using the open-source Extensible Neuroimaging Archive Toolkit (Marcus, Olsen, et al., 2007). It provides tools to search, to visualize, and to download the data. Before down- loading and requesting data, users are asked to abide by the OASIS Data Usage Agreement. OASIS data are distributed in GNU zip archive files, which can be uncompressed using freely available software. All images are distributed in NIFTI1 format (http://nifti.nimh. nih.gov), which can be visualized and processed using many common commercial and open source image viewing ap- plications, including Neurolens, ImageJ, Slicer, and MRIcro. For each imaging session, the following image files are in- cluded in the distribution: three to four individual scan images; an image in which the individual scans have been aligned and coregistered, an image that has been gain field- corrected and registered to the Talairach and Tournoux atlas (T88); a masked T88 image in which the intensity of all nonbrain voxels has been set to zero; and a segmented T88 image in which each voxel has been labeled as gray matter, white matter, or cerebral spinal fluid. Demographic, clinical, and derived imaging measures (Table 4) are avail- able in XML and spreadsheet formats. Additional details of the directory structure, file naming scheme, and image characteristics can be found at http://www.oasis-brains. org/longitudinal_facts.html. DISCUSSION The present data set includes longitudinally acquired T1-weighted MRI data from 150 individuals aged 60 to 96 years, including 64 individuals initially determined to have AD and 14 who were diagnosed with AD at a return visit. Repeated within-visit acquisitions are included for each subject allowing extremely high contrast properties after image averaging. The data have been anonymized, carefully screened for image quality, and postprocessed to generate common anatomic measures. The data are available under a liberal usage policy that allows free access and unrestricted usage to all interested parties. The image files included in this OASIS set differ from the previous OASIS set in two substantive ways meant to im- prove overall usability. First, the files are in the NiFTI 1 im- age format, which is now widely supported and preferred for its more explicit specification of voxel ordering. Second, the images have not been altered to remove facial features. This ensures that fiducial markers placed on the left temple are always present in raw scan images. It also removes hard edges that may cause difficulty in some segmentation algorithms. The specific anatomical measure of nWBV included here illustrates a common approach to analyzing ana- tomical characteristics of the brain in MRI images, par- ticularly in relation to aging. Unsurprisingly, our findings are in agreement with those described in previous studies using portions of these data (e.g., Fotenos et al., 2005). In particular, nWBV was shown to decline significantly with increasing age and by AD status as previously reported by Fotenos et al. (2005) and others (Dickerson et al., 2006; Killiany et al., 2000, 2002; Fox & Freeborough, 1997; Jack et al., 1992, 1997). Similarly, the rate of nWBV decline was significantly greater for the AD group than for the non- demented group. These findings are representative of the types of analyses that have been reported in the literature and are not in- tended to be comprehensive or the final word on how to approach these data. Such issues as the interplay between imaging markers, AD, and other diseases (e.g., hyper- tension, diabetes) remain open avenues for further investi- gation. Similarly, alternative image processing and statistical methods may yield additional findings. We hope that the description and open release of these data will encourage 2682 Journal of Cognitive Neuroscience Volume 22, Number 12 D o w n l o a d e d l l / / / / j t t f / i t . : / / f r o m D h o t w t n p o : a / d / e m d i t f r p o m r c h . s p i l d v i e r e r c c t h . m a i r e . d c u o o m c / n j a o r c t i n c / e a - p r d t i 2 c 2 l e 1 2 - p 2 d 6 f 7 / 7 2 1 2 9 / 4 1 0 2 1 / 7 2 2 6 o 7 c 7 n / 2 1 0 7 0 7 9 0 8 2 4 1 4 8 0 / 7 j o p c d n . b y 2 0 g 0 u 9 e . s t 2 o 1 n 4 0 0 7 8 . S p e d p f e m b y b e r g u 2 0 e 2 s 3 t / j . . . / t f o n 1 8 M a y 2 0 2 1 ongoing exploration of the data, leading to improvements in the diagnosis and treatment of AD. Acknowledgments The authors thank the Washington University ADRC and the Conte Center for clinical assistance and participant recruitment; Elizabeth Grant for assistance with data preparation; Susan Larson, Amy Sanders, Laura Williams, Jamie Parker, and Glenn Foster for assistance with MRI data collection; Avi Snyder for development of analytic techniques; and Tim Olsen, Mohana Ramaratnam, Kevin Archie, and Mikhail Milchenko for development of database and Web tools. Anders Dale assisted with the original selection of imaging parameters. The acquisition of this data and the support for data analysis and management were provided by the National Institutes of Health grant nos. P50 AG05681, P01 AG03991, R01 AG021910, P20 MH071616, RR14075, RR 16594, and BIRN002; the Alzheimerʼs Association; the James S. McDonnell Foundation; the Mental Illness and Neuroscience Discovery Institute; and the Howard Hughes Medical Institute. Reprint requests should be sent to Daniel S. 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S p e d p f e m b y b e r g u 2 0 e 2 s 3 t / j f . . t . / o n 1 8 M a y 2 0 2 1 2684 Journal of Cognitive Neuroscience Volume 22, Number 12

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