FUNCIÓN DE ENFOQUE:
Connectivity, Cognición, and Consciousness
Functional network antagonism
and consciousness
Athena Demertzi1,2,3,4
, Aaron Kucyi5
, Adrián Ponce-Alvarez6
, Georgios A. Keliris7
,
Susan Whitfield-Gabrieli5,8*, and Gustavo Deco6,9,10,11*
1Physiology of Cognition, GIGA Consciousness Research Unit, GIGA Institute (B34), Sart Tilman,
University of Liège, Liège, Bélgica
2Psychology and Neuroscience of Cognition (PsyNCog), Faculty of Psychology, Logopedics and
Educational Sciences, Sart Tilman, University of Liège, Liège, Bélgica
3GIGA-CRC In Vivo Imaging, Sart Tilman, University of Liège, Liège, Bélgica
4Fund for Scientific Research, FNRS, Bruxelles, Bélgica
5Department of Psychology, Northeastern University, Bostón, MAMÁ, EE.UU
6Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and
Communication Technologies, Universitat Pompeu Fabra, Barcelona, España
7Bio-Imaging Lab, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Bélgica
8Northeastern University Biomedical Imaging Center (NUBIC), Northeastern University
Interdisciplinary Science and Engineering Complex (ISEC), Bostón, MAMÁ, EE.UU
9Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona, España
10Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Alemania
11Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging,
Monash University, Clayton, Melbourne, VIC, Australia
*Equal contribution.
Palabras clave: Anticorrelations, Integration, Segregation, Conciencia, Neural inhibition, Funcional
conectividad
ABSTRACTO
Spontaneous brain activity changes across states of consciousness. A particular consciousness-
mediated configuration is the anticorrelations between the default mode network and other
regiones del cerebro. What this antagonistic organization implies about consciousness to date
remains inconclusive. In this Perspective Article, we propose that anticorrelations are the
physiological expression of the concept of segregation, namely the brain’s capacity to show
selectivity in the way areas will be functionally connected. We postulate that this effect is
mediated by the process of neural inhibition, by regulating global and local inhibitory activity.
While recognizing that this effect can also result from other mechanisms, neural inhibition
helps the understanding of how network metastability is affected after disrupting local and
global neural balance. In combination with relevant theories of consciousness, we suggest
that anticorrelations are a physiological prior that can work as a marker of preserved
consciousness. We predict that if the brain is not in a state to host anticorrelations, then most
likely the individual does not entertain subjective experience. We believe that this link
between anticorrelations and the underlying physiology will help not only to comprehend
how consciousness happens, but also conceptualize effective interventions for treating
consciousness disorders in which anticorrelations seem particularly affected.
RESUMEN DEL AUTOR
The fMRI resting paradigm can quantify brain function by surpassing communication and
sophisticated setups, hence helping to infer consciousness in individuals who are unable to
un acceso abierto
diario
Citación: Demertzi, A., Verano, A., Ponce-
Alvarez, A., Keliris, GRAMO. A., Whitfield-
Gabrieli, S., & decoración, GRAMO. (2022).
Functional network antagonism
and consciousness. Red
Neurociencia, 6(4), 998–1009.
https://doi.org/10.1162/netn_a_00244
DOI:
https://doi.org/10.1162/netn_a_00244
Recibió: 1 Octubre 2021
Aceptado: 6 Marzo 2022
Conflicto de intereses: Los autores tienen
declaró que no hay intereses en competencia
existir.
Autor correspondiente:
Athena Demertzi
a.demertzi@uliege.be
Editor de manejo:
Olaf Sporns
Derechos de autor: © 2022
Instituto de Tecnología de Massachusetts
Publicado bajo Creative Commons
Atribución 4.0 Internacional
(CC POR 4.0) licencia
La prensa del MIT
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Anticorrelations and consciousness
Functional anticorrelations:
Negative functional connectivity that
certain brain regions show with
regard to the positive connectivity of
other regions as observed in zero-lag
correlations of BOLD activity.
communicate with their environment. A particular consciousness-mediated rsfMRI
configuration is that of functional anticorrelations, eso es, the antagonistic relationship
between a specific set of brain regions. We suggest that anticorrelations are a key physiological
previo, without which consciousness cannot be supported, because the brain cannot segregate
how regions get connected. We postulate that segregation is possible thanks to neural
inhibition, by regulating global and local inhibitory activity. We believe that the link between
anticorrelations and the underlying physiology can help not only to comprehend how
consciousness happens, but also conceptualize effective interventions for treating its disorders.
INTRODUCCIÓN
Individuals during sleep, anesthesia, and in disorders of consciousness are unable to commu-
nicate intentionally with the environment. Como consecuencia, their mental state needs to be inferred
by means of meaningful proxies. The fMRI resting paradigm has been a great asset to that
asunto, as it quantifies brain function by surpassing the need for communication of experience
or behavioral output (Zhang et al., 2021). En general, studies in such states of consciousness point
to lesser functional connectivity (FC) between regions that are within the same “network,” in
that they show positive FC during wakefulness (Heine et al., 2012). The positive coupling
entre regiones del cerebro, especially those of the default mode network (DMN), was shown to
enable fast and accurate performance during higher order cognitive tasks concerning, para
ejemplo, executive function (Brillo y col., 2016) or working memory (cohen & D'Esposito,
2016). Such integrative profiles reduce dramatically in states of unconsciousness—yet
within-network FC persists and does not entirely disappear (Boveroux et al., 2010; Di Perri
et al., 2016). Por lo tanto, DMN correlations might be more about shaping connectivity interac-
tions rather than reflecting conscious mental activity (Boly et al., 2008).
A rather consciousness-sensitive connectivity profile is that of functional anticorrelations,
eso es, the negative FC that some regions show with the DMN. Depending on the state of
consciousness anticorrelations reduce in intensity, like after sleep deprivation (De Havas
et al., 2012; Yeo et al., 2015), in slow wave sleep and REM (Chow et al., 2013), hypnosis
(Demertzi et al., 2011), and deep sedation (Luppi et al., 2019). Or they are undetectable, como
in deep anesthesia (Boveroux et al., 2010), and unresponsive brain-damaged patients (Di Perri
et al., 2016; Threlkeld et al., 2018). En tono rimbombante, anticorrelations’ FC recovers during the
immediate postanesthetic period (Nir et al., 2020) and after emergence from a disorder of con-
sciousness (Di Perri et al., 2016; Threlkeld et al., 2018). Within the state of typical wakefulness,
the presence of anticorrelations was shown to contributes to cognitive function (j. B. Keller et al.,
2015; Vanhaudenhuyse et al., 2011), with greater intensity leading to better within-subject
(p.ej., Kucyi et al., 2017) and between-subject performance (p.ej., Spreng et al., 2010). También,
anticorrelations seem to contribute to life span, starting weak in children, strengthening during
adolescence, ending up fully anticorrelated in young adulthood (Chai et al., 2014), and getting
selectively decreased during healthy aging (j. B. Keller et al., 2015). Considering that anti-
correlations are implicated in cognition and consciousness, an emerging question is what this
antagonistic configuration implies about the brain’s physiology and conscious experience. A
nuestro conocimiento, no such formulation has been suggested yet. To address this, we discuss con-
ceptual and methodological debates around anticorrelations, y, by tackling their physiolog-
ical underpinnings, we postulate a mechanistic link between micro- and macrocircuitry,
which may explain the function of anticorrelations in the context of conscious experience.
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Anticorrelations and consciousness
Global signal:
BOLD signal time course averaged
across all brain voxels.
FUNCTIONAL ANTICORRELATIONS CONTAIN MEANINGFUL NEURAL ACTIVITY
Anticorrelations refer to brain regions showing negative FC in contrast to the positive FC within
intrinsic networks, such as the DMN. The regions showing negative FC with the DMN concern
primarily the intraparietal sulcus, the frontal eye fields, and the middle temporal + área (Fox
et al., 2005). Históricamente, the areas showing anticorrelations were coined as “task-positive” in
contrast to a “task-negative” DMN (Fox et al., 2005). This connotation was given to highlight,
respectivamente, activations and deactivations exhibited by these systems during task perfor-
mance, initially measured with positron emission tomography, and later confirmed by fMRI
(Raichle & Mintun, 2006). It has been proposed, sin embargo, that the dichotomization between
“task-positive” and “task-negative” might be misleading because it insinuates that the DMN is
not engaged actively in cognitive processes (Spreng, 2012). As the DMN indeed collaborates
with other task-related areas (Elton & gao, 2015) and networks (Spreng, 2012) to promote
cognitive performance and mental flexibility (Spreng et al., 2014), we will here preferentially
utilize the term anticorrelations.
The discussion about anticorrelations very often goes hand in hand with the methodolog-
ical debate about correcting or not for the brain’s global signal (GS) during fMRI data prepro-
cesando. The GS can be obtained by averaging the resting-state time courses over the entire
cerebro (Desjardins et al., 2001). This whole-brain averaging implies the possibility that non-
neuronal sources can contribute to the GS along with neural signal. As most functional con-
nectivity studies are interested in identifying the neural counterparts of a task or a condition,
this implies that GS needs to be accounted for. GS correction can happen via linear regression,
subtraction, or normalization (t. t. Liu et al., 2017). Such a process, sin embargo, can lead to
systematically shifting the distribution of correlation values in the negative direction (anderson
et al., 2011; Murphy et al., 2009) y, entonces, anticorrelations emerge. This implies that anticor-
relations are a matter of mathematical treatment, spurious, and not neuronally meaningful. A
fecha, sin embargo, there is support both for the nonneuronal and the neuronal significance of the
GS. Por un lado, the GS is shown to reflect fMRI nuisance sources such as motion, scan-
ner artifacts, respiration (Power et al., 2017), cardiac rate (Chang & guantero, 2010), and vas-
cular activity (Colenbier et al., 2020; Zhu et al., 2015). Por otro lado, GS is considered to
have a neuronal counterpart (Schölvinck et al., 2010) that promotes behavior (Le et al., 2019),
it was shown to correlate with spontaneous fluctuations in the local field potentials as mea-
sured with implanted electrodes in monkeys (Schölvinck et al., 2010), and it was associated
with vigilance (Wen & Liu, 2016; Wong et al., 2013) and arousal (X. Liu et al., 2018) como
measured with EEG in humans. Juntos, the debate about whether to employ GS correction
as a preprocessing step or not remains unresolved, while the choice can be driven by the
research question at hand (Murphy & Fox, 2017; Uddin, 2017).
Generally, we align with the view that the spontaneous anticorrelations are not mere arti-
facts and that they actually reflect neural activity. This is after considering that GS correction
does not preferentially affect only systems exhibiting positive correlations but also those which
show anticorrelations in the first place (Fox et al., 2009). Anticorrelations between the DMN
and the executive attention system can also be found using independent component analysis
(without GS correction), suggesting that the anticorrelations are not merely a mathematical
issue. También, anticorrelations are shown to increase after caffeine intake, pointing to their phys-
iological dynamism (Wong et al., 2013). The anticorrelations between networks homologous
to DMN and the dorsal attention network (DAN) are also observed in rodents, perros, and non-
human primates, confirming interspecies consistency (Belloy et al., 2018a; Gozzi & Schwarz,
2016; hutchison & Everling, 2012; Szabó et al., 2019). Además, the strength of anticor-
relations is shown to be predictive of disease phenotype (Adhikari et al., 2021; Belloy et al.,
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Anticorrelations and consciousness
Neural inhibition:
A physiological mechanism that
helps sustain balanced cortical
activity by orchestrating the
coordination between excitatory
pyramidal neurons and inhibitory
nonpyramidal cells.
Network metastability:
The ability of network transitioning
among variant functional states
con el tiempo.
2018b; Sripada et al., 2014) and is able to change by means of sensory stimulation, atención,
y neuromodulación (Hinz et al., 2019; Peeters et al., 2020). Finalmente, the existence of spon-
taneous anticorrelated networks is evidenced in computational simulations in monkey and
human brains (Deco et al., 2009), as well as in neurophysiological studies. By means of simul-
taneous scalp EEG and fMRI in humans, a temporal relationship has been found between
increased alpha power and greater DMN-DAN anticorrelations (Chang et al., 2013), highlight-
ing their cognitive relevance. More direct evidence comes from intracranial recordings of local
field potentials (LFPs). In cats, simultaneous recordings of unit activity and LFPs showed that,
when attentional demands increased, LFP power in task-on (DAN-homologue) regions aug-
mented and task-off (DMN-homologue) regions decreased (Popa et al., 2009). Further human
intracranial EEG evidence suggests that during wakeful rest, areas of these networks exhibited
anticorrelated slow fluctuations of high gamma power (C. j. Keller et al., 2013), which was
correlated with neuronal firing rates (Manning et al., 2009). También, high gamma power evoked
by tasks had opposing patterns in the DMN and antagonistic networks as measured by intra-
cranial EEG (Ossandón et al., 2011; Ramot et al., 2012). Finalmente, intracranial EEG supports that
spontaneous, transient increases in high gamma (a proxy for neuronal spiking) regularly arose
within major nodes of the DMN versus DAN/salience networks and were time-locked to cog-
nitive and physiological events (Daitch & Parvizi, 2018; Verano & Parvizi, 2020). Colectivamente,
observational and interventional studies in humans and animals support that anticorrelations
have a physiological and neuronal importance.
NEURAL INHIBITION MEDIATES THE FORMULATION OF ANTICORRELATIONS
We postulate that anticorrelations may be emerging thanks to the process of neural inhibi-
ción. Neural inhibition is a pivotal mechanism for the brain to sustain balanced cortical activ-
idad (Isaacson & Scanziani, 2011). This is done by the orchestrated coordination between
excitatory pyramidal spiking neurons occupying 70%–80% of the cortex and the remaining
inhibitory nonpyramidal cells (DeFelipe & Fariñas, 1992), such that for every five excitatory
synapses there is approximately one inhibitory (Beaulieu & Colonnier, 1985). Excitation and
inhibition happen in a balanced way, leaving it unlikely to observe an increase in one with-
out observing an increase in the other; de lo contrario, no cell would reach firing threshold (Scannell
& Joven, 1999). The recruitment of GABAergic inhibitory interneurons via the thalamus, corti-
cocortical, or other excitation pathways has been shown to assist cognition and motor behavior
(Swanson & Maffei, 2019). También, it is via this synchronous activation of excitatory and inhibitory
activity that anticorrelated cortical network activity emerges (Arthurs & Boniface, 2002;
Logothetis, 2008).
Considering this mechanism in relation to anticorrelations, we do not claim that neural
inhibition directly promotes anticorrelated patterns, eso es, by having networks straightly inhi-
biting one another (of note, most interareal connections are glutamatergic/excitatory). Nor do
we claim that neural inhibition always leads to anticorrelated profiles. Bastante, we suggest that
neural inhibition mediates the rise of the anticorrelations indirectly, by breaking the local neu-
ral balance which affects network metastability and which eventually permits anticorrelations
to appear. More particularly, current computational whole-brain models assume that distant
brain regions establish connections between their corresponding excitatory neural populations
(Cifra 1, E-E blue solid line connectivity). The resulting local increase of excitation produces
an increase of inhibition through the local E-I loop (feedback inhibition). Apart from the inter-
areal excitatory activity, one brain region (A) can also effectively inhibit the activity of a distal
brain region (B), by A targeting B’s inhibitory interneurons (Cifra 1, E-I blue dashed line con-
conectividad), which in turn, locally connect to the pyramidal cells (Cifra 1, I-E red connector;
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Anticorrelations and consciousness
Cifra 1. Functional anticorrelations might emerge as a result of local and long-range inhibitory
actividad. Brain regions are modeled by interconnected populations of excitatory (mi) and inhibitory (I)
neuronas. Long-range excitatory connections from brain region A to brain region B can target the
excitatory population (E → E, solid blue) or the inhibitory population (E → I, dashed blue). The level
of inhibition in region B depends i) on the local E-I loop (local feedback inhibition) and ii) sobre el
excitatory inputs from region A to the inhibitory neurons in region B, which in turn connect locally
to the excitatory cells (long-range feedforward inhibition, gray highlighted path). With this model,
we postulate that neural inhibition assists the emergence of the anticorrelations not by direct inter-
network, interareal inhibition (of note, most interareal connections around the brain are glutamater-
gic). Bastante, anticorrelations appear indirectly after disrupting both local and global balance
between excitation and inhibition, eventually affecting network metastability.
es decir., feedforward inhibition; Isaacson & Scanziani, 2011). Sin embargo, little attention has been
paid to this indirect long-range inhibition in modeling studies and how specifically feedforward
inhibition interacts with the local excitation-inhibition (E/I) ratio. Although previous theoretical
work has separately examined the effect of regulating the E/I ratio through feedback inhibition
or feedforward inhibition in whole-brain models (Deco et al., 2014), a model that takes both effects
into account has not been studied yet. Local heterogenous feedback inhibition, En particular, sig-
nifies that the excitability of local population activity is achieved by variably determining each
region’s gain response function. Recent studies using heterogeneous and homogeneous whole-
brain modeling have mechanistically shown that, besides increasing the level of fitting of the
empirical data, an increase in ignition was observed (Deco et al., 2021). Based on this evidence,
one could speculate that ignition is related to the presence of regional heterogeneity. Aunque el
type of heterogeneity that is the most relevant for ignition remains open, one can nevertheless
say that thanks to heterogeneity in general, ignition-like dynamics may happen (Deco et al.,
2021), which are thought to support conscious experience (ver la siguiente sección).
críticamente, it has been shown that, when feedback projections and randomization of the
connectivity weights were removed, dynamic network behavior was abolished, suggesting that
feedback connectivity and heterogeneity in connection strength gives rise to ignition-like activity
(Joglekar et al., 2018). We here hypothesize that the generation of the anticorrelations can be a
matter of both inhibitory effects (local feedback inhibition, long-range feedforward inhibition),
which will eventually affect network metastability, allowing the emergence of the anticorrelations.
Hasta la fecha, the behavior of this model remains to be theoretically studied and empirically supported.
THE ANTICORRELATIONS’ SIGNIFICANCE TO CONSCIOUSNESS
On our quest to tackle the meaning of the anticorrelations to consciousness we lean toward
theoretical frameworks in order to see how they embrace the mechanism of inhibition. Nosotros
Gain response function:
A model parameter that can be set to
different values across brain regions
that impose various levels of
excitability.
Encendido:
The ability of a given brain area to
propagate feed-forward and
recurrent neuronal activity to other
regiones.
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Anticorrelations and consciousness
Neuronal bistability:
The tendency of cortical neurons to
fall into a silent period (down state)
after an initial activation.
Segregation:
The brain’s capacity to show
selectivity in the way brain areas are
functionally connected.
notice that especially the global neuronal workspace theory (GNWT; Dehaene et al., 2003)
and the integrated information theory (IIT; Oizumi et al., 2014) are two such theories that uti-
lize inhibition when accounting for consciousness in their models.
The GNWT describes how reportable experience happens. The theory proposes a model
with various local processors that are all linked at a central executive. Its model suggests to
view the local processors as specialized modular cortical areas that process specific percep-
tual, motor, memory, and evaluative information. The central executive (composed of widely
distributed excitatory neurons) can be considered as a second computational space, cual
forms reciprocal connections to specific processor neurons. Based on this architecture, en
any moment, a piece of information within one or several processors can be selected, ampli-
fied, and broadcasted to all other processors, thus rendering it consciously accessible and
available for reporting. This global broadcasting happens thanks to ignition (Dehaene et al.,
2003; Mashour et al., 2020). Ignition is characterized by the sudden, coherent, and exclusive
activation of a subset of workspace neurons that codes the current conscious content, mientras
the remainder of the workspace neurons remain inhibited. Regardless of how ignition may be
triggered, simulations show that if feedforward connections are carefully balanced by local
inhibitory influences, incoming stimuli elicit a stable cascade of activity characterized by a
late and sudden ignition. En otras palabras, ignition of a global neural state coding for particular
conscious content leads to the active inhibition of other potential contents (as we also showed
antes; Vanhaudenhuyse et al., 2011).
The IIT begins the quest of consciousness by experience itself. The theory first identifies the
experience’s essential properties (axioms) and then infers what kind of properties a physical
system must have in order to account for these properties (postulates). The postulates specify
which conditions (such as neurons and their connections) must be satisfied by physical mech-
anisms to account for the phenomenology of experience. To generate consciousness, a phys-
ical system must be able to discriminate among a large repertoire of states (información), y eso
must be doing so as a single system, therefore not decomposable into a collection of causally
independent parts (integración). For integrated information to be high, a system must be con-
nected in such a way that information is generated by causal interactions among its parts,
rather than within them. In balanced states, the corticothalamic system is a fine example of
a functionally integrated and specialized network, able to generate high values of integrated
information peaks that are characterized by a complex spatiotemporal pattern of signal prop-
agations in different directions (feedforward, comentario, contralateral) and with variant weights,
including inhibitory. In unbalanced states, like those of low arousal, the cortical neurons are
inactivated due to the neuronal bistability of their membrane potential or active inhibition, y
thus cannot specify a conceptual structure. In that case, the system then collapses, conduciendo a
low values of integrated information, and hence diminished conscious experience.
If we try to link the inhibitory mechanisms described in these models with functional anti-
correlations, we can observe that these promote the notion of functional segregation. En eso
respeto, anticorrelations can be considered as an FC segregated profile, which mediates various
states of consciousness. In the past, Fox et al. (2005) similarly suggested that “while correlations
may serve as an integrative role in combining neuronal activity subserving similar goals or rep-
resentaciones, anticorrelations may serve as a differentiating role segregating neuronal processes,
subserving opposite goals or competing representations” (Fox et al., 2005, pag. 9677). This view
on segregation refers to the ability of a system to distinguish information into distinct modules
that can perform specialized local computations (shannon, 1948). This definition may slightly
deviate from how graph theory considers segregation, eso es, close to the notion of modularity
and as a measure of the relative strength between a graph’s nodes (despreciar, 2013). In that respect,
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Anticorrelations and consciousness
inhibition as described in the GNWT can be viewed as the segregative processes that hinder
widespread FC, leading to negative functional correlations. Similarmente, differentiation as described
in the IIT can be similarly considered as parallel to the processes of segregation, also expressed
as anticorrelated FC.
Tomados juntos, our view is that anticorrelations are the physiological expression of segre-
gation, and we propose that neural inhibition is the mediating link. Our stance, por supuesto, does
not prevent other measures from being linked to unconsciousness. En efecto, low values in sam-
ple entropy (which quantifies how unpredictable a signal is; Luppi et al., 2019) or “small-
worldeness” (which allows for a cost-efficient network organization; Uehara et al., 2014)
are also affected in reduced consciousness. We also remain mindful of the fact that anticorre-
lations can still result by fMRI preprocessing steps, as described above, or from changes in the
hemodynamics in some regions or even from time delays that produce phase lags. The DAN,
por ejemplo, was found to precede DMN deactivation by up to hundreds of milliseconds
(Kucyi et al., 2020; Raccah et al., 2018). One possible explanation for that is that the anti-
correlations are driven by sequences of spontaneous neuronal population events across the
DMN and antagonistic systems that involve interregional temporal delays (Kucyi et al.,
2020). The observed zero-lag anticorrelations could therefore be due to “blurring” of such
delays, meaning anticorrelations could be the result of transient events that are comprised
of spontaneous activations that are systematically coupled to subsequent DMN deactivations,
as observed in transient coactivation patterns at rest (Karahanoğlu & Van De Ville, 2015; X. Liu
& duyn, 2013). Sin embargo, this hypothesis requires further investigation. These issues keep our
hypothesis about anticorrelations being a metric of consciousness in check and call for
experimental and mechanistic explanations.
Colectivamente, we consider that FC anticorrelations are an essential ingredient for conscious
mental activity and might work as another marker of preserved consciousness. Nosotros, por lo tanto,
predict that if the brain is not in a state to host the physiological prior of inhibitory activity, entonces
most likely the individual does not entertain subjective experience. This stance opens new
avenues for the understating and treatment of clinical cases of consciousness alternations
by targeting anticorrelations specifically as the outcome measure, like it has been shown using
neurofeedback (Bauer et al., 2020) or meditation (Bauer et al., 2019) for psychiatric disorders.
We think that the introduction of yet another metric is justified by the difference this metric
makes and the pragmatic issues it addresses (Demertzi et al., 2017). Por eso, we align with the
view that, when searching for consciousness, accumulative evidence stemming from multiple
nonoverlapping assessments with different modalities needs to be applied (Seth et al., 2008)—
ideally, those that receive theoretical framing in order to account for the mechanistic expla-
nations of the metric at hand. What this view of the anticorrelations essentially offers is a link
between the level of neuronal microcircuitry and the computational level, which starts gaining
support when attempting to describe how consciousness happens (Changeux, 2017).
CONCLUSIONS
We suggest that the FC anticorrelations emerge thanks to local and global neural inhibitory
actividad, which leads to variant spatiotemporal configurations. Such rich network organization
was previously shown to characterize typical conscious conditions, while simpler interre-
gional connectivity was most frequently seen in anesthetized states and states of low report-
capacidad (Barttfeld et al., 2014; Demertzi et al., 2019; Huang et al., 2020). We eventually invite
researchers to view anticorrelations as the physiological expression of segregation via neural
inhibition, which can help us not only comprehend how consciousness happens, pero también
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Anticorrelations and consciousness
conceptualize and design effective interventions for treating consciousness disorders in which
anticorrelations seem particularly affected.
EXPRESIONES DE GRATITUD
We would like to thank Mr. Fort Larry, M.A., for proofreading the manuscript for grammar and
syntax.
CONTRIBUCIONES DE AUTOR
Athena Demertzi: Conceptualización; Investigación; Administración de proyecto; Recursos;
Escritura – borrador original; Escritura – revisión & edición. Aaron Kucyi: Investigación; Recursos;
Validación. Adrián Ponce-Alvarez: Metodología; Validación; Visualización; Escritura – revisión
& edición. Georgios A. Keliris: Investigación; Metodología; Recursos; Validación. Susan
Whitfield-Gabrieli: Recursos; Supervisión; Validación. Gustavo Deco: Metodología;
Recursos; Supervisión; Validación; Visualización.
INFORMACIÓN DE FINANCIACIÓN
Athena Demertzi, Fonds De La Recherche Scientifique – FNRS (https://dx.doi.org/10.13039
/501100002661).
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